LipoSwift LNP - In Vivo Skin-Targeting Kit

The in vivo series is developed using proprietary lipid nanoparticle (LNP) technology, systematically designed to meet diverse in vivo nucleic acid application needs, achieving high delivery efficiency, precise targeting, and excellent biocompatibility. One of the key features of this series of kits is its ease of use while maintaining a high transfection efficiency. It is designed for a simple, single-step encapsulation process that does not require any specific LNP encapsulation equipment.

The LipoSwift LNP – In Vivo Skin-Targeting Kit is an advanced LNP delivery system specifically engineered for high-efficiency and selective nucleic acid delivery to skin tissue in live animal models. The skin, as the largest organ of the body, is a prime target for a wide range of therapeutic applications, including the treatment of inflammatory diseases like atopic dermatitis and psoriasis, genetic conditions such as epidermolysis bullosa, wound healing, and even skin cancer. However, the skin's natural barrier function makes it notoriously difficult to penetrate and deliver payloads effectively to the desired cellular layers, such as the epidermis or dermis. Through a finely tuned and patented lipid formulation, our kit achieves exceptionally high and selective accumulation of the LNP-nucleic acid complex in the skin. This kit is an indispensable tool for researchers and developers working on dermatological research, organ-specific studies, the creation of novel therapeutic strategies for skin-related diseases, and transfection observation.

• Precise Skin Targeting: The formulation is optimized for preferential accumulation in skin tissue following administration. This is achieved through careful tuning of particle size, surface charge, and lipid hydrophobicity, resulting in enhanced penetration and retention in the epidermis and dermis.
• Broad Payload Compatibility: The kit can encapsulate various nucleic acid types, including mRNA, siRNA, saRNA, circRNA, and shRNA, enabling a wide range of applications in basic research and therapeutic development.
• Single-Step Encapsulation Without Special Equipment: The kit enables encapsulation in one simple step using standard laboratory pipettes, drastically reducing the time and cost associated with LNP preparation.
• High Transfection Efficiency: Performance benchmarks show that LNPs prepared with this kit achieve transfection efficiencies comparable to LNPs made with professional encapsulation systems, ensuring that researchers do not compromise on data quality when opting for simplicity.
• Excellent Biocompatibility: The proprietary lipid composition of LipoSwift nanoparticles is optimized for low immunogenicity and high stability in physiological environments, ensuring minimal adverse effects and better tolerability in vivo.
• Stable & Reproducible: Batch-to-batch consistency ensures reliable particle characteristics, encapsulation efficiency, and delivery outcomes.

The efficacy and specificity of the LipoSwift LNP - In Vivo Skin-Targeting Kit have been rigorously validated through extensive preclinical studies. A key demonstration of the kit's performance involves the delivery of mRNA, showcasing highly specific gene expression in the skin, and high dose dependence and extremely low dose transfection.

LipoSwift LNP - In Vivo Skin-Targeting Kit User Manual