Pharmacokinetic Study

Pharmacokinetics, sometimes abbreviated as PK, is a branch of pharmacology dedicated to describing how the body's effects on a specific substance after administration of a drug. Pharmacokinetics generally examines four main parameters: absorption, distribution, metabolism, and excretion (ADME). Pharmacokinetic information is collected in order to guide the selection of doses and treatment schedules for oligonucleotide therapeutics for clinical reference. Alfa Chemistry has a professional technology platform for the pharmacokinetic study of oligonucleotide therapeutics. If you need help, please contact us.

ADME

Absorption

Oligonucleotide therapeutics cannot be delivered by oral administration because their gastrointestinal absorption is low as a consequence of their high molecular weight, hydrophilicity, and charge. Therefore, oligonucleotide therapeutics are generally administered intravenously, and there are some oligonucleotide therapeutics on the market that are administered by gavage, intraperitoneal injection, intrathecal injection or intravitreal injection. Many biological analysis methods can be used to quantitatively analyze the concentration of drugs and their short chain oligonucleotide metabolites in animal plasma, such as HPLC, ELISA, CGE-UV, HPLC-UV, IP-HPLC-ES/MS, etc.

Distribution

Most oligonucleotide therapeutics are rapidly distributed in tissues and have relatively consistent tissue distribution signs. That is, they are distributed in many tissues, among which the highest distribution is in the kidney, followed by the liver, and the lowest is in the brain. Quantitative whole body autoradiography (QWBA) method can be used to determine the radioactivity concentration of oligonucleotide therapeutics in various tissues of animals and to study their tissue distribution.

Metabolism

Metabolism is the process by which a drug is transformed in the body to make it more hydrophilic so that it can be excreted through the kidneys. The metabolism of oligonucleotide therapeutics must be evaluated since drugs are foreign substances in the human body. In vitro, LC-MS/MS can be used to determine oligonucleotide therapeutic concentrations in liver microsomes and hepatocytes of various species.

Excretion

Excretion is the removal of a substance from the body. Drugs are either excreted unchanged or partially excreted as metabolites in urine or bile, or through natural routes such as tears, sweat, breathing, saliva, etc. Liquid scintillation counting (LSC) can be used to determine the radioactive concentration of drugs in urine and feces to provide information on the material balance.

What We Offer?

With experienced experts and state-of-the-art equipment, Alfa Chemistry is able to provide customers with pharmacokinetic study services and related technical advice for oligonucleotide therapeutics. Our nonclinical evaluation technology platform has the following advantages:

Our products and services are for research use only and cannot be used for any clinical purposes.

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