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Oligonucleotide drugs are emerging as promising treatments for a wide range of diseases, offering hope to millions of patients worldwide. Recent advancements in various types of oligonucleotide therapeutics, including antisense, aptamer, small interfering RNA (siRNA), and microRNA (miRNA), have driven the increasing demand for cost-effective and large-scale production solutions. To meet this demand, it is essential to establish an efficient technology platform for oligonucleotide synthesis, enabling the seamless transition from research-scale production to large-scale manufacturing.
Alfa Chemistry is at the forefront of oligonucleotide development and synthesis. We have three main technology platforms: solid phase oligonucleotide synthesis (SPOS), liquid phase oligonucleotide synthesis (LPOS) and liquid-solid coupled synthesis. Each platform offers distinct advantages based on the application requirements, production scale, and desired level of customization.
SPOS is one of the breakthrough achievements in nucleic acid chemistry. Combined with well-established automation technology, it allows for the rapid assembly of oligonucleotides with desired sequences and modifications, though in limited quantities. Synthetic methods typically use solid-phase phosphoramidite chemistry that involves iterative coupling, capping, oxidation, and deprotection steps to extend nucleotide sequences.
As an alternative strategy, LPOS uses homogeneous reaction mixtures, which are in principle infinitely scalable and require smaller reagent excesses. As a result, LPOS becomes another platform with unique advantages, especially when large-scale production is required. The platform is based on soluble supports, allowing the growing oligonucleotides to be separated from the reaction medium through membrane filtration or precipitation.
The liquid-solid coupled synthesis platform is a major breakthrough in the field of oligonucleotide synthesis, as it combines the best features of SPOS and LPOS. This innovative synthesis method meets the ever-increasing needs of cutting-edge research and clinical development, contributing to significant advancements in personalized medicine, drug discovery, and molecular diagnostics.
Recognizing the diverse needs of our clients, Alfa Chemistry offers extensive customization options for oligonucleotide synthesis. Whether requiring specific modifications, such as fluorescent labels or functional groups, or scaling up from research quantities to bulk production, our technology platforms can accommodate a wide range of specifications.
With a team of experienced scientists and technicians, Alfa Chemistry provides unparalleled technical support throughout the synthesis process. From the initial consultation to the final product delivery, our experts will guide customers in selecting the synthesis strategies and conditions that best suit their specific application.
Cost-effectiveness is an important consideration for many research institutions and companies. Alfa Chemistry leverages its advanced technology and streamlined processes to offer competitive pricing without compromising on quality. Our pricing model is designed to meet the budget needs of different customers while maintaining the highest standards of quality and service.
Oligonucleotide synthesis platforms are indispensable in driving groundbreaking innovation across a broad spectrum of scientific disciplines, from molecular biology and genomics to drug discovery and therapeutic development. Alfa Chemistry is dedicated to technology and process development, striving to build internationally leading oligonucleotide synthesis platforms. If you are interested in our technology platform or have any questions, please feel free to inquire.
Our products and services are for research use only and cannot be used for any clinical purposes.
As a specialist in oligonucleotide therapeutics, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.
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