Aptamer Development

Aptamers are single-stranded DNA, RNA, or altered nucleic acids sequences with a strong affinity for specific target binding generated by the systematic evolution of ligands by exponential enrichment (SELEX) technology^[1]. Some aptamers can regulate the function of target proteins by binding to target proteins. Although aptamers recognize and bind targets of interest just like antibodies, they have a number of advantages, such as shorter generation time, lower costs of manufacturing, no batch-to-batch variability, higher modifiability, better thermal stability and higher target potential ranging from ions to live animals. Due to these characteristics of aptamers, they have been widely used in detection, diagnosis imaging analysis and drug targeted therapy for tumors.

With comprehensive and advanced technology platforms, Alfa Chemistry provides therapeutic aptamer development services for customers around the world. We have absolute credibility in the field of drug research and development, so contact us today if you need help.

Applications of Aptamers

For clinical diagnosis

The high affinity and specificity of aptamers make them ideal diagnostic agents with the potential to replace conventional antibodies in clinical diagnosis. Like monoclonal antibodies, aptamers can be used for the molecular recognition of their respective targets. Aptamers have been successfully used for pathogen recognition, cancer recognition, monitoring environmental contamination, and as stem cell markers.

For the treatment of diseases

Due to the ability of aptamers to compete with small molecules or protein ligands and to inhibit their targets, they are considered to be promising therapeutics. A number of aptamers have entered clinical trials for the treatment of ocular diseases, hematologic diseases, cancer, and more. In addition, Pegaptanib, a vascular endothelial growth factor (VEGF)-specific aptamer, was approved for therapeutic use in age-related macular degeneration.

For targeted drug delivery

Aptamers have been used successfully for the delivery of a variety of therapeutic reagents into target cells and tissues. Aptamer-based delivery systems include aptamer therapeutic oligonucleotide conjugates, aptamer-drug conjugates, and aptamer-decorated nanomaterials. Examples of aptamers used for targeted drug delivery are shown in Table 1^[2].

Table 1. Aptamers for the targeted drug delivery.

Our Services

Alfa Chemistry provides therapeutic aptamer and other aptamer development services. Our experts are passionate about providing our customers with a high quality one-stop service. If you need help, please contact us.

Therapeutic aptamer development services

• Target selection.
• Sequence design of aptamers.
• Synthesis and chemical modification of aptamers.
• Screening of aptamers (SELEX technology)
• Delivery system selection or development of aptamers.
• Nonclinical evaluation of aptamers.
• Scale-up of aptamers.

Other aptamer development services

• Diagnostics aptamer development.
• Aptamer-based delivery system development.

Our products and services are for research use only and cannot be used for any clinical purposes.

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