Aptamers are single-stranded DNA, RNA, or altered nucleic acids sequences with a strong affinity for specific target binding generated by the systematic evolution of ligands by exponential enrichment (SELEX) technology[1]. Some aptamers can regulate the function of target proteins by binding to target proteins. Although aptamers recognize and bind targets of interest just like antibodies, they have a number of advantages, such as shorter generation time, lower costs of manufacturing, no batch-to-batch variability, higher modifiability, better thermal stability and higher target potential ranging from ions to live animals. Due to these characteristics of aptamers, they have been widely used in detection, diagnosis imaging analysis and drug targeted therapy for tumors.
