Polymeric Nanoparticle-Based Delivery Systems

Nanoparticles constructed from polymers, termed polymeric nanoparticles (PNPs), have been extensively explored in the delivery of various antitumor drug formulations due to their flexibility in tuning the physical-chemical properties for efficient drug loading and controllable release. The structural versatility also endows PNPs with great opportunities in carrying oligonucleotide therapeutics through multiple strategies, such as electro-adsorption by cationic polymer micelles, or physical encapsulation within the cavity of polymer vesicles^[1].

Advantages of PNP Delivery Systems

In oligonucleotide therapeutic delivery, PNPs play a significant role by efficiently bringing the active ingredient to purposed position within the human body. PNP delivery systems have the following characteristics or advantages.

• In drug delivery applications, PNPs can be easily integrated into other activities such as tissue engineering.
• PNPs offer the advantage of precise targeting and controlled release, ensuring that the active ingredients reach their designated tissue or organ at the required concentration. Additionally, they provide stability and a prolonged activity duration for volatile active ingredients.

Polymers Used for PNP Delivery Systems

There are two main types of polymers used in PNPs formulation, namely natural polymers and synthetic polymers.

Preparation Techniques for PNPs

Solvent evaporation, nanoprecipitation, salting-out and dialysis techniques, and supercritical fluid techniques can be used to prepare PNPs from already preformed polymers^[2]. Moreover, PNPs can be meticulously crafted through the polymerization of monomers using various polymerization mechanisms, including controlled radical polymerization, emulsion, surfactant-free emulsion, mini-emulsion, micro-emulsion, and interfacial polymerization.

How We Do?

Alfa Chemistry is proficient in the drug delivery technology of oligonucleotide therapeutics and provides solutions to improve the delivery efficiency and security of oligonucleotide therapeutics. You can also order polymer raw materials directly from us for delivery technology research.

Our products and services are for research use only and cannot be used for any clinical purposes.

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