LipoSwift LNP - In Vivo Immune Cell Kit

LipoSwift LNP - In Vivo Immune Cell Kit

The kit is an advanced solution for the in vivo targeted delivery of nucleic acids to key immune cell populations, built on our proprietary lipid nanoparticle (LNP) platform. Read More

Catalog Number: ONT-LNP009

Size: 0.4mL; 1mL; 2mL

RNA: 100μg; 500μg; 1000μg

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Description

Key Advantages

Data Showcase

User Manual

The in vivo series is developed using proprietary lipid nanoparticle (LNP) technology, systematically designed to meet diverse in vivo nucleic acid application needs, achieving high delivery efficiency, precise targeting, and excellent biocompatibility. One of the key features of this series of kits is its ease of use while maintaining a high transfection efficiency. It is designed for a simple, single-step encapsulation process that does not require any specific LNP encapsulation equipment.

The LipoSwift LNP - In Vivo Immune Cell Kit is an advanced solution for the in vivo targeted delivery of nucleic acids to key immune cell population. In the rapidly evolving fields of immunotherapy and vaccine development, the ability to specifically manipulate immune cells is crucial. Our in vivo immune cell Kit enables efficient delivery of nucleic acids, including mRNA, siRNA, saRNA, and circRNA, into critical immune cell populations such as macrophages, dendritic cells, and other antigen-presenting cells (APCs) directly within living organisms. By delivering functional payloads into these cells, researchers can modulate immune pathways, enhance antigen presentation, or reprogram immune responses for therapeutic purposes. This allows for a wide range of applications, from designing next-generation mRNA vaccines and developing novel cell therapies to studying the fundamental mechanisms of immune regulation.

This kit represents a significant step forward in our commitment to providing innovative tools for life sciences. It simplifies the complex process of in vivo immune cell targeting, making it a powerful resource for scientists working to develop safer and more effective immunotherapies and vaccines.

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  • Immune Cell–Specific Targeting: The lipid composition and surface chemistry are optimized for preferential uptake by immune cells (particularly macrophages and dendritic cells) within the reticuloendothelial system. This specificity minimizes off-target delivery to non-immune tissues and enhances the functional impact on the desired cell population.
  • High Transfection Efficiency in Immune Cells: Achieving efficient nucleic acid delivery to immune cells has traditionally been challenging due to their strong endocytic pathways and innate immune sensing. LipoSwift's optimized formulation enhances both cellular uptake and endosomal escape, resulting in superior transfection rates and effective expression or silencing of target genes.
  • Versatility for Multiple Payload Types: While optimized for mRNA delivery, the kit is also compatible with other nucleic acids such as siRNA, saRNA, and circRNA. Researchers can adapt the formulation to fit a variety of immune modulation strategies.
  • Single-Step Encapsulation Without Special Equipment: The kit enables encapsulation in one simple step using standard laboratory pipettes, drastically reducing the time and cost associated with LNP preparation.
  • Excellent Biocompatibility: The proprietary lipid composition of LipoSwift nanoparticles is optimized for low immunogenicity and high stability in physiological environments, ensuring minimal adverse effects and better tolerability in vivo.
  • Scalability for Preclinical Studies: The protocol can be scaled from small pilot experiments to larger preclinical animal studies without compromising particle quality or immune cell targeting efficiency.

To validate the exceptional performance of the LipoSwift LNP - In Vivo Immune Cell Kit, we have conducted a series of rigorous in vivo studies. These results highlight the immune cell–targeting specificity of our product, particularly toward macrophages and dendritic cells.

Our products and services are for research use only and cannot be used for any clinical purposes.

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