Polyvinylpyrrolidone (PVP) is a synthetic polymer with good biocompatibility and transparency, which can undergo crosslinking and form PVP-based hydrogels under the action of different stimuli such as radiation, heat, pressure, chemicals, etc. PVP-based hydrogels are very promising for different biomedical applications due to their tissue compatibility, tissue-like consistency, and other excellent physical and chemical properties.
Preparation
The preparation methods of PVP-based hydrogels mainly include radiation techniques and freezing-thawing or freezing-thawing in combination with irradiation.
PVP-based hydrogels can be obtained by radiation techniques in several ways, including irradiation of pure polymers, monomers or solution of polymers and/or monomers in bulk. Common radiation techniques include γ- radiation, electron beam radiation and ultraviolet (UV) radiation. Among them, UV irradiation takes a very short time to form reliable PVP-based hydrogels.
- Freezing-thawing or freezing-thawing in combination with irradiation
Another preparation method of PVP-based hydrogels is repeated freezing-thawing or freezing-thawing in combination with irradiation. Freezing-thawing is refer to the polymer solution is kept under very cold conditions for a duration, called freezing, then the temperature of the polymer solution is raised to room temperature for a duration, called thawing. The cycle is repeated several times.
Applications
PVP-based hydrogels as biomaterials have been proposed for a wide range of biomedical applications like wound healing, transdermal drug delivery, oral drug delivery, and as substitutes for skin, tendons, ligaments, cartilage, and bone. This is because PVP-based hydrogels contain a high amount of water and have good biocompatibility, high elasticity and mechanical strength, and good chemical stability and durability[1]. In addition, PVP-based hydrogels are widely used in soft contact lens preparation, waste water treatment, hydrocarbon degradation, food packaging, water retainers for agriculture, and so on.
Our Products
Alfa Chemistry is a leading global supplier of hydrogels. Our experienced scientists focus on the production and performance improvement of PVP-based hydrogels. Our products include but are not limited to the following. Please contact us to customize the PVP-based hydrogels you need, and we will provide you with high quality products according to your detailed requirements.
- Polyvinylpyrrolidone (PVP) hydrogel
- Polyvinyl alcohol (PVA)/polyvinylpyrrolidone (PVP) binary composite hydrogel
- Polyvinylpyrrolidone (PVP)/carboxymethyl cellulose (CMC) composite hydrogel
- K-type carrageenan/polyvinylpyrrolidone (PVP) blended hydrogel
- Chitosan/polyvinylpyrrolidone (PVP) composite hydrogel
- Polyvinyl alcohol (PVA)/polyvinylpyrrolidone (PVP)/ water-soluble chitin (WS-chitin) composite hydrogel
Reference
- Pal, P.; et al. Modified PVP based hydrogel: synthesis, characterization and application in selective abstraction of metal ions from water. Materials Chemistry and Physics. 2017, 194: 261-273.
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