Biological Property Analysis of Hydrogels
Hydrogels as biomedical materials in controlled drug delivery, tissue engineering, and wound dressing have drawn considerable attention because of their complex reticulation and structural resemblance to the extracellular matrix. Biological properties should be analyzed during the development of hydrogels, such as biocompatibility, cytotoxicity, biodegradability, etc., which are crucial for the safety assessment of hydrogels in different applications. Alfa Chemistry has a biology laboratory with many experienced biology experts. Over the years, we have worked with many well-known companies or academic institutions and successfully helped them analyze the biological properties of multiple hydrogels, which has driven the marketization of their hydrogel-based products.
Analysis Items and Methods
Alfa Chemistry provides consumers with professional biological property analysis services for hydrogels, and our analysis items include but not limited to the following.
Biocompatibility of hydrogels refers to their ability to be applied without causing a host reaction. Biocompatibility is made up of bio-functionality and bio-safety. Bio-functionality is the capacity of hydrogels to do the precise task for which they are designed. Bio-safety is the correct host response with no cytotoxic, mutagenic and/or carcinogenic effects both systemic and local. The assessment methods of biocompatibility applied to hydrogels usually involve chemical analysis, tissue culture, and animal tests.
Cytotoxicity of hydrogels includes qualitative and quantitative tests. Qualitative tests are comprised of the direct contact procedure, the agar diffusion assay, and the minimum essential medium (MEM) elution assay. Quantitative tests usually involve MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazoline bromide) and/or XTT (2,3-bis(2-methoxy-4nitro-5-sulphophenyl)-5-[phenylamine)carbonyl]-2H tetrazolium hydroxide) assays.
Biodegradability of hydrogels is critical in biomedicine. Generally, hydrogels may degrade and be cleared from the body by bio-erosion and bio-absorption. The process by which hydrogels are degraded into harmless byproducts by living organisms is referred to as biodegradability, which is affected by the moieties as well as the preparation methods of hydrogels. Other elements, such as temperature and pH, might affect hydrogel breakdown through simple solubilization. Therefore, we analyze the biodegradability of hydrogels by combining their basic properties and use environment.
Our Advantages
- We offer biological property analysis services for a wide range of hydrogels, ranging from pure hydrogels to composite hydrogels.
- We have professional cell culture techniques to ensure the accuracy of hydrogel biological property data.
- We provide flexible and targeted technical support 24 hours a day, 7 days a week to reduce your time costs.
- We offer a complete analysis report, including method interpretation, data, result files and other information you need.
Service Process
Please kindly note that our products and services are for research use only.
