| Catalog Number | NZs86867018 |
| CAS | 86867-01-8 |
| Structure |  |
| Description | S-(5'-adenosyl)-L-methionine chloride dihydrochloride (SAM) facilitates the transfer of methyl groups to proteins, lipids, and nucleic acids. |
| Synonyms | SAM, Active methionine, AdoMet, SAM chloride dihydrochloride |
| Molecular Weight | 507.82 |
| Molecular Formula | C15H23ClN6O5S·2HCl |
| Canonical SMILES | Cl.Cl.[Cl-].C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23 |
| Purity | ≥75% |
| Solubility | H2O: 100 mg/mL |
| Appearance | powder |
| Application | Therapeutically, SAM can be used as a nutritional supplement for various conditions, including osteoarthritis and liver damage. SAM also regulates transsulfuration reactions by binding to the regulatory domain of the key enzyme cystathionine-β-synthase (CBS). |
| Beilstein | 6560002 |
| Biochem Physiol Actions | Methionine adenosyltransferase catalyzes the synthesis of SAM from methionine and adenosine triphosphate (ATP). SAM regulates various cellular functions, such as cell division, cell death, transcription, genetic stability, oxidative/antioxidant balance, and polyamine homeostasis. |
| Biological Source | synthetic (chemical) |
| Color | white to off-white |
| MDL Number | MFCD22571809 |
| NACRES | NA.32 |
| Storage Conditions | Please store this product at -20℃. |
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