Catalog NumberNZs1631137217
CAS Number1631137-21-7
CategoryZymogens
| Description | Human Plasma α2-Macroglobulin (A2M) is a large plasma glycoprotein that acts as a broad-spectrum protease inhibitor. It captures and inactivates various proteases through a "molecular trap" mechanism, forming stable enzyme-inhibitor complexes. For research use only. Not intended for human or therapeutic use. |
| Synonyms | α2-M |
| Molecular Weight | ~720 kDa |
| Purity | ≥98% by SDS-PAGE |
| Appearance | White to off-white powder |
| Application | Used in studies of protease regulation, inflammation, and coagulation cascades. Also applied in research on neurodegenerative diseases, cytokine transport, and protein-protein interaction dynamics. |
| Biochemical/Physiological Action | A2M inhibits both serine and metalloproteases by covalently trapping them within its structure. It also binds cytokines and growth factors, regulating immune responses and maintaining plasma protease homeostasis. |
| MDL Number | MFCD00130472 |
| Storage Conditions | It is recommended to store this product at -20°C. |
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