Catalog NumberNZs140208237
CAS Number140208-23-7
CategoryZymogens
| Description | Human PAI-1 is the primary physiological inhibitor of tPA and uPA, regulating fibrinolysis and maintaining hemostatic balance. It belongs to the serpin (serine protease inhibitor) family. For research use only. Not intended for human or therapeutic use. |
| Synonyms | PAIE, PLANH1, Plasminogen activator inhibitor, β-migrating endothelial cell-derived type, Serpin E1 PAI-1, Serpine 1 |
| Molecular Weight | ~43 kDa |
| Purity | ≥90% by SDS-PAGE |
| Appearance | Powder |
| Application | Used in studies of thrombosis, cardiovascular disease, and cancer metastasis. Also serves as a biomarker for metabolic and inflammatory disorders. |
| Biochemical/Physiological Action | PAI-1 inhibits plasminogen activators by forming stable complexes, thereby controlling plasmin generation and fibrin degradation. Overexpression contributes to thrombosis and tissue fibrosis. |
| MDL Number | MFCD01094930 |
| Storage Conditions | It is recommended to store this product at -20°C. |
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