Catalog NumberNZs000940
CategoryZymogens
| Description | Human Neuroserpin is a neuronally expressed serine protease inhibitor that primarily targets tissue plasminogen activator (tPA). It is essential for regulating proteolysis in the nervous system. For research use only. Not intended for human or therapeutic use. |
| Synonyms | Protease inhibitor 12, Serpin I1 |
| Molecular Weight | 44.6 kDa |
| Purity | ≥96% by SDS-PAGE |
| Appearance | White to off-white powder |
| Application | Used in neurobiology and neuropathology research to study synaptic plasticity, neuroprotection, and neurodegenerative diseases such as familial encephalopathy with neuroserpin inclusion bodies (FENIB). |
| Biochemical/Physiological Action | Neuroserpin forms inhibitory complexes with tPA, modulating extracellular proteolysis in the brain. Dysregulation leads to protein aggregation and neuronal damage. |
| Storage Conditions | It is recommended to store this product at -20°C. |
| WGK Germany | 3 |
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