Catalog NumberNZs844499714
CAS Number844499-71-4
CategoryEnzyme Activators
| Description | Potent, reversible AMPK activator (EC50 = 0.8 µM) |
| Synonyms | 6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile |
| Molecular Weight | 360.39 |
| Molecular Formula | C20H12N2O3S |
| Canonical SMILES | C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O |
| InChI Key | CTESJDQKVOEUOY-UHFFFAOYSA-N |
| Purity | >98% |
| Solubility | Soluble in DMSO (100 mM) |
| Application | Stimulates glucose uptake; decreases fatty acid synthase levels; inhibits MSC proliferation |
| Storage | We recommend storing this product at 4 °C. |
| Mechanism | Activates AMPK allosterically; inhibits AMPK dephosphorylation; Na+/K+-ATPase inhibitor (IC50: rat 57 µM, human 220 µM) |
| Packaging | 10mg, 50mg |
| Recommended Usage | We strongly recommend preparing and using the solution on the same day. If storage is necessary, keep the solution at -20 °C for up to one month. Before use, allow the solution to equilibrate to room temperature and ensure that it is free of any precipitate. |
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