Sulfopropylated-Gamma-Cyclodextrin Sodium Salt
INQUIRY
Sulfopropylated-Gamma-Cyclodextrin Sodium Salt
Abbreviation SPGCD2
Catalog CD-DR09
Cyclodextrin Type Cyclodextrin Derivatives
Packaging 1 g
Quality Fine chemical grade
Storage Condition Store in an airtight container at room temperature.
Availability In stock
*On-demand pack size is available, please contact us for multi-kilograms pack sizes.
Product Description
Sulfopropylated-gamma-cyclodextrin sodium salt (SP-GCD-Na) is synthesized by introducing sulfopropyl groups into the gamma-cyclodextrin molecule, resulting in a highly water-soluble, anionic compound. The modification enhances the molecule's interaction with hydrophobic guest molecules, significantly improving their solubility and bioavailability.
Basic Information
| Molecular Formula | C48H80-nO40·(C3H6O3SNa)n |
| Formula Weight | 1297.2+n·(144.1) |
| Possible Impurities | Gamma-hydroxypropylsulfonic acid sadium salt, gamma-cyclodextrin |
| Solubility (in 100 cm3 solvent, at 25 °C) | Water: >50 g, Methanol:<0.5 g, Acetone: <0.5 g |
Detailed Information
Physical & Chemical Properties
| Appearance | white to slight yellow powder |
| Average degree of substitution (n) | 1.0-3.0 |
| Purity | >95% |
| Loss on drying | <10% |
Impurities
| Residual gamma-hydroxypropyl-sulfonic acid sodium salt | <0.5% |
| Residual gamma-cyclodextrin | <1.0% |
Mechanism of Action
The functionality of SP-GCD-Na is primarily driven by its ability to form inclusion complexes with hydrophobic molecules. The gamma-cyclodextrin core provides a hydrophobic cavity that can encapsulate guest molecules, while the sulfopropyl groups on the exterior increase the solubility and stability of the overall complex. This dual functionality is crucial in various applications:
- Enhanced Solubilization - The sulfopropyl groups introduce negative charges that improve the aqueous solubility of poorly soluble drugs, increasing their dissolution rate and bioavailability.
- Stability Improvement - Encapsulation protects sensitive guest molecules from environmental factors such as light, oxygen, and heat, extending shelf life and enhancing stability.
- Selective Complexation - The gamma-cyclodextrin cavity size is ideal for larger molecules, making it particularly suitable for complexing with steroids, macrocycles, and other large hydrophobic compounds.
Applications
SP-GCD-Na has emerged as a valuable excipient in pharmaceutical formulations, owing to its ability to improve the physicochemical properties of active pharmaceutical ingredients (APIs). Key applications include:
Drug Solubilization and Delivery
SP-GCD-Na is widely used to solubilize poorly water-soluble drugs, enhancing their therapeutic efficacy. This is particularly beneficial for oral, injectable, and topical formulations.
Controlled Release Systems
By encapsulating drugs within its hydrophobic cavity, SP-GCD-Na can modulate the release profile, offering controlled or sustained release capabilities, which are essential for drugs with narrow therapeutic windows.
Taste Masking
The inclusion complexation can also mask the unpleasant taste of certain drugs, enhancing patient compliance, especially in pediatric and geriatric formulations.
Stabilization of Biopharmaceuticals
SP-GCD-Na provides protective encapsulation for sensitive biomolecules, such as peptides, proteins, and nucleotides, preventing degradation and ensuring bioactivity.
Related Products
Alfa Chemistry leverages over two decades of expertise in cyclodextrin chemistry to offer high-quality, customizable sulfopropylated-gamma-cyclodextrin sodium salt tailored to your application needs. Our state-of-the-art production facilities and rigorous quality control ensure consistent performance and compliance with the highest industry standards. For more information or to request a quote, please contact us.
It should be noted that our our products and services are for research use only, not for clinical use.
