Sulfopropylated Alpha-Cyclodextrin Sodium Salt
INQUIRY
Sulfopropylated Alpha-Cyclodextrin Sodium Salt
Abbreviation SPACD2
Catalog CD-DR10
Cyclodextrin Type Cyclodextrin Derivatives
Packaging 1 g
Quality Fine chemical grade
Storage Condition Store in an airtight container at room temperature.
Availability In stock
*On-demand pack size is available, please contact us for multi-kilograms pack sizes.
Product Description
At the heart of sulfopropylated alpha-cyclodextrin sodium salt is alpha-cyclodextrin, a cyclic oligosaccharide composed of six glucose units linked by α-(1,4)-glycosidic bonds. This unique structure forms a truncated cone-shaped molecule with a hydrophobic interior and a hydrophilic exterior, enabling it to encapsulate hydrophobic guest molecules.
The sulfopropylation of the alpha-cyclodextrin occurs through the addition of sulfopropyl functional groups (-SO3-), which are introduced onto the hydroxyl groups present on the glucose units. These modifications not only increase the molecule's aqueous solubility but also provide a charged surface that enhances interaction with various substrates, particularly in electrostatic or ionic conditions.
Basic Information
| Molecular Formula | C48H80-nO40·(C3H6O3SNa)n |
| Formula Weight | 1297.2+n·(144.1) |
| Possible Impurities | Gamma-hydroxypropylsulfonic acid sadium salt, gamma-cyclodextrin |
| Solubility (in 100 cm3 solvent, at 25 °C) | Water: >50 g, Methanol:<0.5 g, Acetone: <0.5 g |
Detailed Information
Physical & Chemical Properties
| Appearance | white to slight yellow powder |
| Average degree of substitution (n) | 1.0-3.0 |
| Purity | >95% |
| Loss on drying | <10% |
Impurities
| Residual gamma-hydroxypropyl-sulfonic acid sodium salt | <0.5% |
| Residual gamma-cyclodextrin | <1.0% |
Synthesis Method
The preparation of sulfopropylated alpha-cyclodextrin sodium salt involves the reaction of alpha-cyclodextrin with a sulfopropylating agent, typically 1,3-propanesultone, in an alkaline medium.
A. Activation of Alpha-Cyclodextrin: Alpha-cyclodextrin is dissolved in an aqueous medium, and the pH is adjusted to an alkaline range (pH 9-11) using a base such as sodium hydroxide.
B. Sulfopropylation: 1,3-propanesultone is added slowly to the solution. The reaction is typically conducted at temperatures between 25°C to 40°C, allowing controlled substitution without degradation of the cyclodextrin ring.
C. Neutralization and Precipitation: The reaction is neutralized with an acid (e.g., hydrochloric acid), and the product is precipitated, usually by adding an organic solvent like ethanol or acetone.
D. Purification: The precipitated product is filtered, washed, and dried under vacuum to obtain the purified Sulfopropylated Alpha-Cyclodextrin Sodium Salt in solid form.
Applications
Sulfopropylated alpha-cyclodextrin sodium salt is employed in drug formulation and delivery systems due to its ability to enhance the solubility of poorly water-soluble drugs. It acts as a solubilizer, enabling the encapsulation of hydrophobic active pharmaceutical ingredients (APIs), thereby improving bioavailability and stability.
- Chemical Catalysis and Separation
In the chemical industry, Sulfopropylated Alpha-Cyclodextrin Sodium Salt is utilized in separation processes and as a chiral catalyst. Its ability to interact with chiral molecules enables it to be used in enantioselective reactions, where it acts as a template for the preferential synthesis of one enantiomer over the other.
In cosmetic formulations, Sulfopropylated Alpha-Cyclodextrin Sodium Salt serves as a stabilizing agent and solubilizer for hydrophobic ingredients such as vitamins, antioxidants, and fragrances. Its non-toxic and biocompatible nature makes it suitable for use in skin-care products and hair treatments.
Related Products
Alfa Chemistry leverages over two decades of expertise in cyclodextrin chemistry to offer high-quality, customizable sulfopropylated-alpha-cyclodextrin sodium salt tailored to your application needs. Our state-of-the-art production facilities and rigorous quality control ensure consistent performance and compliance with the highest industry standards. For more information or to request a quote, please contact us.
It should be noted that our our products and services are for research use only, not for clinical use.
