Kulkarni M, et al. Materials Today Communications, 2024, 39, 109202.
Sulfobutylether-β-cyclodextrin sodium (SBECD) was employed to form inclusion complexes with Niclosamide monohydrate (NCL), aiming to improve the solubility, dissolution rate, and oral bioavailability of NCL. Various preparation methods were used to form the NCL-SBECD complexes, including co-grinding, kneading, solvent evaporation, and spray drying, with a 1:1 molar ratio of NCL to SBECD. The co-ground complex was prepared by manually mixing NCL and SBECD in a mortar for 10 minutes. The kneaded complex involved mixing the NCL-SBECD mixture with a hydroalcoholic solution, followed by drying and sieving. For the co-evaporated complex, NCL was dissolved in acetone, and SBECD was dissolved in water, with the solvent mixture evaporated under controlled conditions at 60°C. The spray dried complex was prepared by dissolving NCL and SBECD in acetone and water, respectively, followed by mixing and drying using a spray dryer under specific operational conditions, including a feed rate of 12 mL/min, inlet temperature of 120°C, and outlet temperature of 60°C. These findings highlight the potential of SBECD as a versatile excipient in drug delivery systems to improve the therapeutic effectiveness of poorly soluble drugs.
