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Cyclodextrins are enzyme modified starch derivatives. They are cyclic oligosaccharides composed of glucose units linked with α-1,4 glycosidic bonds. The chiral glucose units are in a rigid chair conformation, making the cyclodextrin molecule shaped like a hollow truncated cone with secondary hydroxyl groups on the wider rim and primary hydroxyl groups on the narrower rim. To date, a variety of cyclodextrin compounds have been developed, which can be divided into two categories: modified cyclodextrins and cyclodextrin inclusion complexes.

• Modified cyclodextrin: Modified cyclodextrins, also known as cyclodextrin derivatives, are obtained by introducing substituents into the basic skeleton of the macrocycle of the parent cyclodextrin. Theoretically, cyclodextrin can undergo a variety of reactions, and O-H, C-H, C-O and C-C bonds can all be broken. There are various types of cyclodextrin derivatives, which may have different substitution sites, different types of substituents, and different average degrees of substitution (DS).
• Cyclodextrin inclusion complexes: Due to its unique structure, cyclodextrin can encapsulate hydrophobic molecules within its cavity and form host-guest inclusion complexes with guest molecules driven by electrostatic, van der Waals interactions, and hydrogen bonding [1]. There are various types of cyclodextrin inclusion complexes, which can include guest molecules of different sizes and types according to their different cavity structures.

These cyclodextrin compounds exhibit different inclusion capacities and physicochemical properties and can be characterized by a variety of analytical methods, thus facilitating the development of their applications.

Our Cyclodextrin Services

Alfa Chemistry provides analytical services and custom synthesis services. We are not only dedicated to the characterization of cyclodextrin compounds through a variety of analytical methods, but also capable of synthesizing different cyclodextrin derivatives and cyclodextrin inclusion complexes according to customers' needs. We aim to help customers expand the application areas of cyclodextrin and commercialize cyclodextrin products in multiple fields.

Analytical Services

Alfa Chemistry has a modern analytical testing laboratory equipped with state-of-the-art testing equipment. With our comprehensive cyclodextrin analysis services such as HPLC, GC, NMR, CE and MS, your products can meet specific performance requirements.

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Custom Synthesis

Alfa Chemistry offers a full range of custom synthesis services for different cyclodextrin applications. We can design synthesis routes according to customers' needs and provide cyclodextrin derivatives with desired structures and molecular weights.

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Guided by a customer-oriented philosophy, our experts and research technicians leverage their extensive analytical and synthetic knowledge to provide customers with the highest quality cyclodextrin services. From the project design stage to the result, our experts will always work closely with clients to help them reduce costs and time while maximizing high-quality products and reliable analytical data output.

It should be noted that our our products and services are for research use only, not for clinical use.