Paeonol-Hydroxypropyl-β-Cyclodextrin Complex

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Paeonol-Hydroxypropyl-β-Cyclodextrin Complex

Catalog CD-IC26

Cyclodextrin Type Cyclodextrin inclusion complex

Packaging 100 g

Storage Condition Store in a tightly sealed container away from heat and direct light, and in a cool dry place

Availability In stock

*On-demand pack size is available, please contact us for multi-kilograms pack sizes.

Product Description

Paeonol, a natural phenolic compound known for its antioxidant properties, is often utilized in various applications due to its health benefits. In contrast, β-cyclodextrin, a cyclic oligosaccharide derived from starch, possesses a unique cavity structure that enables it to effectively encapsulate other molecules. The paeonol-hydroxypropyl-β-cyclodextrin inclusion complex (PAE-HP-β-CD) is a complex formed by incorporating the paeonol (PAE) molecule into the hydroxypropyl-β-cyclodextrin (HP-β-CD) molecule. This inclusion complex serves as a significant functional material, largely because of its molecular encapsulation capability. By integrating paeonol into the HP-β-CD framework, the solubility and stability of paeonol are substantially enhanced. This improvement not only magnifies its effectiveness but also broadens its potential applications in the pharmaceutical field and beyond.

Specification

Characteristics

• Enhanced solubility. Paeonol, in its natural state, exhibits low solubility in water, which can limit its bioavailability within the body. However, when it forms an inclusion complex with β-cyclodextrin, this solubility is markedly improved. This enhancement allows for easier absorption and utilization of paeonol by the body, thereby potentially increasing its therapeutic effects and overall efficacy.
• Improved stability. The formation of the inclusion complex significantly contributes to the stability of paeonol. By encapsulating the paeonol molecules within the β-cyclodextrin cavity, the complex effectively protects the active compound from degradation or inactivation that can occur during storage or processing. This heightened stability ensures that paeonol maintains its beneficial properties over time, making it more reliable for various applications.
• Augmented antioxidant activity. As a potent natural antioxidant, paeonol is known for its ability to combat oxidative stress. When combined with β-cyclodextrin in the inclusion complex, its antioxidant efficacy is notably enhanced. This synergistic effect aids in safeguarding cells from damage inflicted by free radicals, thereby offering greater protection against oxidative-related conditions. The enhanced antioxidant activity of the PAE-HP-β-CD underscores its potential as a valuable therapeutic agent in promoting cellular health and mitigating oxidative damage.

Applications

• Drug delivery system. The inclusion complex formed between paeonol and β-cyclodextrin is often utilized as a crucial component of drug delivery systems. This combination significantly enhances the pharmacological effectiveness and bioavailability of paeonol, making it particularly well-suited for the formulation of oral and injectable medications. By improving the transport and release profiles of the drug, the complex ensures that paeonol can reach its target sites more efficiently while maximizing its therapeutic benefits.

• Additional applications. Beyond its use in pharmaceuticals, the PAE-HP-β-CD holds promise across various other industries, including food and cosmetics. In the food sector, it can enhance the stability and efficacy of bioactive compounds, thus improving product quality. Similarly, in cosmetics, the complex may bolster the stability and absorption of active ingredients, leading to more effective formulations. Overall, the versatility of this complex underscores its potential to add value and improve performance across a wide range of applications.

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