Methyl-Beta-Cyclodextrin

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Methyl-Beta-Cyclodextrin

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Methyl-Beta-Cyclodextrin

Abbreviation MEBCD

Catalog CD128446366

CAS Number 128446-36-6

Cyclodextrin Type Randomly substituted cyclodextrins, neutral

Packaging 10 kg

Storage Condition Store at room temperature, in tightly closed container

Availability In stock

*On-demand pack size is available, please contact us for multi-kilograms pack sizes.

Product Description

Methyl-beta-cyclodextrin, abbreviated as MEBCD or MCD, is a methylated derivative of native β-CD. It is a cyclic oligosaccharide composed of seven glucopyranose units and shaped like a hollow truncated cone. Due to the presence of a hydrophobic core, MEBCD has inclusion properties and has a higher affinity for cholesterol. Compared with native CDs, MEBCDs are very soluble in organic solvents, less hygroscopic and have a lower surface tension. Due to the various advantages they exhibit, MEBCDs are extensively used as excipients in drug formulations to increase the permeability of cells, which increases the uptake of small molecules such as glucose ^[1]. Custom bulk orders of this product are available upon request.

Basic Information

Average Molecular Formula	C₄₂H_70-nO₃₅·(CH₃)_n
Average Molecular Weight	1135 + n·(14.0)
Average Degree of Subtitution	7.0-13.3
Possible Impurities	Chloride, beta-cyclodextrin
Solubility	Soluble in water, methanol, DMF. Insoluble in acetone, chloroform.

Detailed Information

Physical & Chemical Properties

Appearance	White powder
Odor	Slightly sweet
Content	Min.98.0%
Appearance of aqueous solution (2.5 g/25 ml)	The solution is clear.
pH	5.0-7.5
Specific optical rotation	+154° - +165°
Loss on drying	Max. 7.0%
Residue on ignition	Max. 0.5%

Impurities

Light absorbing impurities	A₂₃₀-A₃₅₀: max. 1.0 A₃₅₀-A₇₅₀: max. 0.1
Residual beta-cyclodextrin (β-CD)	Max. 0.2%
Residual chloride	Max. 0.2%
Heavy metals	Max. 10 ppm

Microorganism

Total aerobic microbial count (TAMC)	Max. 1000 cfu/g
Total yeast and mold count (TYMC)	Max. 100 cfu/g
Escherichia coli	Not detectable

Applications

MEBCD can be used to encapsulate drug molecules and assist in solubilizing them. The main application of MEBCD is as an excipient in the pharmaceutical industry. For example, some protease inhibitor drugs have low solubility or limited permeability. When MBECD is co-formulated with these poorly absorbed drugs, the pharmacokinetic profile of the molecules can be improved, which in turn improves bioavailability ^[2].

Methyl-Beta-Cyclodextrin

MEBCD was used to enclose saquinavir (SQV), an HIV-1 protease inhibitor drug, for improving the solubility of SQV. This encapsulation method possesses economic and technical advantages. In addition to increasing SQV solubility, MEBCD has a certain inhibitory effect on the P-glycoprotein (P-gp) function of small intestinal epithelial cells, which increases SQV bioavailability in vivo, as P-gp limits SQV's oral bioavailability and tissue penetration. In summary, MEBCD has both solubilizing ability and P-gp inhibitory activity, leading MEBCD-based SQV oral formulations to facilitate its further clinical application ^[2,3].

Related Products

As one of the leading CD companies, Alfa Chemistry has a dedicated team which has accumulated extensive expertise in the field of CD chemistry. We offer high quality MEBCDs in multi-kilogram quantities tailored to the special needs of the pharmaceutical and other industries. We do our best to provide customers with first-class products and services. For more information, please feel free to contact us.

References

Mundhara, N.; et al. Methyl-β-cyclodextrin, an actin depolymerizer augments the antiproliferative potential of microtubule-targeting agents. Scientific Reports. 2019, 9: 7638.
Pathak, S. M.; et al. Enhanced oral absorption of saquinavir with methyl-beta-cyclodextrin—preparation and in vitro and in vivo evaluation. European Journal of Pharmaceutical Sciences. 2010, 41(3-4): 440-451.
Jain, R.; et al. Evasion of P-gp mediated cellular efflux and permeability enhancement of HIV-protease inhibitor saquinavir by prodrug modification. Int J Pharm. 2005, 303(1-2): 8-19.

It should be noted that our our products and services are for research use only, not for clinical use.

Product Description

Basic Information

Detailed Information

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