Glucosyl-Beta-Cyclodextrin

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Glucosyl-Beta-Cyclodextrin

Catalog CD92517027

CAS Number 92517-02-7

Cyclodextrin Type Substituted cyclodextrins

Packaging 10 kg

Storage Condition Store in a tightly sealed container away from heat and direct light, and in a cool dry place

Availability In stock

*On-demand pack size is available, please contact us for multi-kilograms pack sizes.

Product Description

Glucosyl-beta-cyclodextrin, also known as 6-O-alpha-D-glucosyl-beta-cyclodextrin, abbreviated as Glu-β-CD or G1-β-CD, is a branched CD with an inner cavity similar to β-CD. It is obtained by attaching a glucose unit to an OH group of β-CD through α-(1,6) linkage. Glu-β-CD has higher solubility and lower hemolysis than parent β-CD ^[1]. It is worth noting that Glu-β-CD, as a CD derivative, can be synthesized not only chemically but also enzymatically. Since chemical synthesis has certain safety issues, it is safer and preferred to use biological enzymatic synthesis. Among all enzymatically synthesized branched CDs, Glu-β-CD is the most intensively studied one. It shows a huge application prospects in food, medicine, analytical testing, environmental protection and other industries ^[2].

Basic Information

Detailed Information

Physical & Chemical Properties

Microorganism

Applications

Glu-β-CD, as a CD derivative, is often used for chromatographic separation in the field of analytical chemistry. Some isomers coexist with the target product and are difficult to separate. Glu-β-CD has the ability to form inclusion complexes with compounds of specific structures, which uses the structural differences between the compounds as a separation mechanism.

For example, Glu-β-CD was used to separate the isomers of asiaticoside B (a kind of oleanane pentacyclic triterpene) by coordination chromatography when added to the mobile phase. Due to its cavity structure, Glu-β-CD can form inclusion complexes with asiaticoside B isomers, with the apparent formation constant (KF) being 2534L/mol. It was speculated that the methyl part in the E ring of asiaticoside B entered the cavity of Glu-β-CD, and the large glycoside part was kept outside, forming hydrogen-bond interaction with the exterior of Glu-β-CD cavity. The different hydrogen bond interactions facilitate the chromatographic separation of asiaticoside B isomers ^[3].

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As one of the leading CD manufacturers, Alfa Chemistry has a dedicated team that has accumulated extensive expertise in the field of CD chemistry. We offer high quality glucosyl-β-CD in multi-kilogram quantities tailored to the special needs of the pharmaceutical and other industries. We do our best to provide customers with first-class products and services. For more information, please feel free to contact us.

It should be noted that our our products and services are for research use only, not for clinical use.