Gamma-Cyclodextrin
Abbreviation GCD
Catalog CD17465860
CAS Number 17465-86-0
Cyclodextrin Type Native, neutral
Packaging 25 kg
Storage Condition Store at room temperature, in tightly closed container
Availability In stock
*On-demand pack size is available, please contact us for multi-kilograms pack sizes.
Product Description
Gamma-cyclodextrin, also abbreviated as γ-CD, is a kind of native CD besides alpha (α)-CD and beta (β)-CD. It is also a cyclic oligosaccharide derived from glucose, composed of eight glucose units linked by α-1,4-glycosidic bonds. The molecule has the shape of a tapered cylinder with 8 primary alcohol groups on one face and 16 secondary alcohol groups on the other face. Like other native CDs, its exterior surface is somewhat hydrophilic whereas its interior core is hydrophobic. So it can form host-guest complexes with various organic molecules in aqueous solutions. Notably, γ-CD has a larger cavity than β-CD, so the cavity can accommodate a wider range of guest molecules.
Basic Information
| Molecular Formula | C48H80O40 |
| Molecular Weight | 1297.2 |
| Possible Impurities | Other cyclodextrins, linear oligomers |
| Solubility (in 100 cm3 solvent, at 25 °C) | Water: > 20.0 g
Methanol: < 1.0 g
DMSO: > 20 |
Detailed Information
Physical & Chemical Properties
| Appearance | White or almost white powder |
| Content | 97.0% - 102.0% |
| Appearance of aqueous solution (10 mg/ml) | The solution is clear and colorless. |
| pH | 5.0-8.0 |
| Reducing sugars | Max. 0.2% |
| Loss on drying | Max. 11.0% |
Identification
| Identification: Specific optical rotation | +174 °C to +180 °C |
| Identification: HPLC | Conforms with reference |
Impurities
| Light absorbing impurities (1%) | A230-A350: max. 0.10
A350-A750: max. 0.05 |
| Heavy Metals | Max. 5.0 ppm |
| Sulfated ash | Max. 0.1% |
Microorganism
| Total aerobic microbial count (TAMC) | Max. 1000 cfu/g |
| Total yeast and mold count (TYMC) | Max. 100 cfu/g |
Applications
Compared with α- and β-CD, γ-CD has a larger inner cavity, higher water solubility and higher bioavailability, and therefore has wider application in many industries, especially in the food and pharmaceutical industries. In the food industry, γ-CD has been proposed as a food ingredient and additive in various food and nutraceutical applications. In the pharmaceutical industry, the use of γ-CD has also been intensively studied. Besides increasing the solubility of drugs, it can also reduce irritation caused by drugs [1].
- In the food industry
- It can be used as a carrier and stabilizer for many bulky guests, such as fat-soluble vitamins, polyunsaturated fatty acids, sensitive colors, and unique flavors from herbs, spices, fruits, etc.
- It can be used in food formulations as it can stabilize and protect certain sensitive colors and unique flavors during many rigorous food processing processes such as freezing, thawing and microwaving, thereby retaining the color or flavor of the food over an extended period of time.
- It can also be used to stabilize fat and oil emulsions, which is useful in the preparation of bread spreads.
- In the pharmaceutical industry
- It can be used to significantly improve the solubility and dissolution of drugs. Formulating poorly soluble drugs with γ-CD can effectively improve their apparent solubility and prevent crystallization of active ingredients.
- It can be used to improve the bioavailability of poorly soluble drugs by increasing the solubility or enhancing the membrane permeability of the drug, resulting in improving its pharmacological effect and reducing the dose of the drug.
- It can be used to encapsulate oils/liquids or volatile active ingredients in molecular cavities, resulting in solid powders, which makes it easier to formulate tablets.
Related Products
As one of the leading CD companies, Alfa Chemistry has a dedicated team which has accumulated extensive expertise in the field of CD chemistry. We offer high quality γ-CDs in multi-kilogram quantities tailored to the special needs of the pharmaceutical and other industries. We do our best to provide customers with first-class products and services. For more information, please feel free to contact us.
Reference
- Li, Z.; et al. Gamma-Cyclodextrin: a review on enzymatic production and applications. Appl Microbiol Biotechnol. 2007, 77(2): 245-55.
It should be noted that our our products and services are for research use only, not for clinical use.
