Ferulic Acid-β-Cyclodextrin-Complex

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Ferulic Acid-β-Cyclodextrin-Complex

Catalog CD-IC31

Cyclodextrin Type Cyclodextrin inclusion complex

Packaging 1 kg

Storage Condition Store in a tightly sealed container away from heat and direct light, and in a cool dry place

Availability In stock

*On-demand pack size is available, please contact us for multi-kilograms pack sizes.

Product Description

Ferulic acid (FA) is a natural antioxidant known for its anti-inflammatory properties. However, its application in biomedicine is limited due to its low solubility in aqueous solutions and susceptibility to photodegradation and oxidative degradation. The formation of an inclusion complex with β-cyclodextrin (β-CD) can significantly enhance the physicochemical properties of FA. By encapsulating FA molecules within the hydrophobic cavity of β-CD, this complexation method effectively inhibits the photodegradation and enzymatic breakdown of FA, thereby increasing its solubility and chemical stability in aqueous environments. Moreover, the formation of the FA-β-CD complex improves the bioavailability of FA by enhancing its ability to penetrate biological membranes, leading to increased cellular uptake and more uniform distribution within the body.

Specification

Advantages

• Enhanced solubility. FA typically exhibits low solubility in water, which can limit its usability in formulations and drug delivery. However, by forming a complex with β-CD, its solubility in aqueous environments is significantly increased, facilitating easier formulation and administration.
• Improved stability. β-CD acts as a protective agent for FA, shielding it from external factors such as light and heat. This protection enhances the stability of FA, reducing its degradation during storage and usage.
• Increased bioavailability. The improved solubility of the FA-β-CD complex enhances its absorption within the body, potentially leading to increased bioavailability. This means that a greater proportion of the active compound is available for therapeutic action.
• Reduced side effects. By refining the drug release characteristics, the FA-β-CD complex may help in minimizing the side effects associated with the drug's action within the body. This controlled release reduces the chances of adverse reactions.
• Sustained release effect. β-CD can function as a sustained release carrier, controlling the release rate of FA and thereby prolonging its therapeutic effects. This allows for a more consistent and extended duration of action, improving overall treatment efficacy.

Applications

• Pharmaceutical formulations. The FA-β-CD complex holds promise for the development of anti-inflammatory medications, potentially beneficial in the treatment of conditions such as rheumatoid arthritis and inflammatory bowel disease.

• Drug delivery systems. The FA-β-CD complex can be further engineered into nanoparticle carriers, enabling targeted drug delivery. This advanced delivery system can increase the therapeutic efficacy and safety of ferulic acid in the body, ensuring that the drug reaches specific sites while minimizing systemic exposure and potential side effects.

• Functional foods and nutritional supplements. The stabilization and improved absorption of ferulic acid through encapsulation with β-cyclodextrin enhance its anti-inflammatory and antioxidant properties. This makes the FA-β-CD complex an ideal candidate for inclusion in functional foods and nutritional supplements, offering augmented health benefits in these consumer products.

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It should be noted that our our products and services are for research use only, not for clinical use.