EGCG-β-Cyclodextrin-Complex

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EGCG-β-Cyclodextrin-Complex

Catalog CD-IC36

Cyclodextrin Type Cyclodextrin inclusion complex

Packaging 100 mg, 1 g

Storage Condition Store in a tightly sealed container away from heat and direct light, and in a cool dry place

Availability In stock

*On-demand pack size is available, please contact us for multi-kilograms pack sizes.

Product Description

Epigallocatechin gallate (EGCG), the primary active constituent of green tea, is renowned for its potent antioxidant and anticancer properties. However, its instability in aqueous solutions and physiological conditions, coupled with a tendency to undergo oxidative degradation, poses significant challenges for its clinical application and pharmaceutical development. Additionally, EGCG's low oral bioavailability further limits its therapeutic potential. To address these issues, beta-cyclodextrin (β-CD) has emerged as a safe and effective drug carrier that can significantly enhance EGCG's physicochemical properties and biological activity. The formation of an EGCG-β-CD-complex involves the encapsulation of EGCG molecules within the hydrophobic cavity of β-CD. This encapsulation markedly improves the water solubility and thermal stability of EGCG, effectively safeguarding it against oxidative degradation and photodecomposition. Furthermore, the EGCG-β-CD-complex exhibits improved pharmacokinetic properties in vivo. By extending the circulation time of EGCG, it enhances its bioactivity within the body. This innovative complexation strategy not only boosts the stability and bioavailability of EGCG but also augments its clinical efficacy, paving the way for its more widespread use in therapeutic applications.

Specification

Advantages

• Enhanced stability. The EGCG-β-CD-complex effectively protects EGCG from degradation in neutral or alkaline environments, thereby significantly prolonging its stability within the body.
• Improved solubility. Through encapsulation of EGCG's hydrophobic segments within the hydrophobic cavity of beta-cyclodextrin, the EGCG-β-CD-complex substantially increases the water solubility of EGCG.
• Boosted bioavailability. By increasing the solubility and stability of EGCG, the EGCG-β-CD-complex aids in promoting its absorption and bioavailability within the body. This improvement ensures that a higher proportion of EGCG can exert its therapeutic effects, thereby optimizing its efficacy.
• Enhanced anticancer activity. At the cellular level, the EGCG-β-CD-complex exhibits a markedly stronger ability to inhibit tumor cell proliferation and induce apoptosis compared to free EGCG. This enhanced anticancer activity is attributed to the complex's improved stability and bioavailability, which amplify its potency in fighting cancer cells.

Applications

The EGCG-β-CD-complex holds promising applications in drug development and functional foods due to its enhanced properties:

• Drug development. By improving the stability, solubility, and bioavailability of EGCG, the EGCG-β-CD-complex facilitates the development of more effective pharmaceutical formulations. This is particularly beneficial for the development of drugs that fully exploit the antioxidant and anticancer properties of EGCG.

• Functional foods. Due to its enhanced absorption and bioactivity, the EGCG-β-CD-complex can be incorporated into dietary supplements and functional food products. These applications aim to provide consumers with the health benefits of EGCG, such as antioxidant and anticancer effects, in a more bioavailable form.

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It should be noted that our our products and services are for research use only, not for clinical use.