Beta-Cyclodextrin
Abbreviation BCD
Catalog CD7585399
CAS Number 7585-39-9
Cyclodextrin Type Native, neutral
Packaging 25 kg
Storage Condition Store at room temperature, in tightly closed container
Availability In stock
*On-demand pack size is available, please contact us for multi-kilograms pack sizes.
Product Description
Beta-cyclodextrin, also abbreviated as β-CD, is a cyclic oligosaccharide produced from starch prepared from partially hydrolyzed starch by an enzymatic process. It is a heptasaccharide derived from glucose, with the seven glucose subunits linked end to end via α-1,4 linkages. The structure is shaped like a tapered cylinder with seven primary alcohols on one face and fourteen secondary alcohol groups on the other. Its ease of production and low price make it the most popular native CD on the market. In addition, the ability to encapsulate hydrophobic guest molecules also makes β-CD suitable for the controlled release, separation and adsorption of drugs [1].
Basic Information
| Molecular Formula | C42H70O35 |
| Molecular Weight | 1135.0 |
| Possible Impurities | Other cyclodextrins, linear oligomers |
| Solubility (in 100 cm3 solvent, at 25 °C) | Water: < 2.0 g
Methanol: < 1.0 g
DMSO: > 10 g |
Detailed Information
Physical & Chemical Properties
| Appearance | White or almost white powder |
| Content | 98.0% - 102.0% |
| Appearance of aqueous solution (10 mg/ml) | The solution is clear and colorless |
| pH | 5.0-8.0 |
| Reducing sugars | Max. 1.0% |
| Loss on drying | Max. 16.0% |
Identification
| Identification: Specific optical rotation | +159 °C to +164 °C |
| Identification: HPLC | Conforms with reference |
| Identification: Iodine test | Yellow-brown precipitate |
Impurities
| Light absorbing impurities (1%) | A230-A350: max. 0.10
A350-A750: max. 0.05 |
| Residual alpha-cyclodextrin (α-CD) | Max. 0.25% |
| Residual gamma-cyclodextrin (γ-CD) | Max. 0.25% |
| Other related impurities | Max. 0.50% |
| Heavy Metals | Max. 10 ppm |
Microorganism
| Total aerobic microbial count (TAMC) | Max. 1000 cfu/g |
| Total yeast and mold count (TYMC) | Max. 100 cfu/g |
Applications
β-CD is the most easily available, economical and useful of native CDs. It has various applications across industries to develop and improve product performance and quality, such as the pharmaceutical industry, the cosmetic and food industry. In industrial production, β-CD can serve as a good excipient, flavoring agent, stabilizer, emulsifier, preservative, and quality improver.
- In the pharmaceutical industry
β-CD is widely used in drug delivery because it can increase the stability and solubility of drugs and reduce their irritation, toxicity, side effects, and unpleasant odor. In addition, it can also be used as a drug formulation as a means of targeting drug delivery and controlling the release of therapeutic ingredients [2].
Besides being used as a stabilizer in personal care products, CD can also be used as an ingredient in fragrances and essential oils.
β-CD can absorb unpleasant odors in food by forming inclusion complexes with odor molecules, thereby covering up or eliminating bad odors. It can not only be used as a fat replacer and texturizer in processed foods, but also as a stabilizer and sustained-release agent for spices, pigments and other substances, encapsulating these unstable compounds in food into the cavities of β-CD and stably releasing them. Besides, β-CD can be used as a thickener and emulsifier in dairy products.
Related Products
As one of the leading CD companies, Alfa Chemistry has a dedicated team which has accumulated extensive expertise in the field of CD chemistry. We offer high quality β-CDs in multi-kilogram quantities tailored to the special needs of the pharmaceutical and other industries. We do our best to provide customers with first-class products and services. For more information, please feel free to contact us.
References
- Hu, J. Environmentally sensitive hydrogel in deodorant fiber application. 8 - Environmentally sensitive polymer gel and its application in the textiles field. Shape Memory Polymers and Textiles. 2007, 252-278.
- Fatima, N.; et al. Beta-Cyclodextrin: A cyclodextrin derivative and its various applications. Polymer Science: Peer Review Journal. 2023, 4(5): PSPRJ. 000597.
It should be noted that our our products and services are for research use only, not for clinical use.
