Beta-Cyclodextrin Phosphate Sodium Salt
INQUIRY
Beta-Cyclodextrin Phosphate Sodium Salt
Abbreviation PBCD26
Catalog CD199684612
CAS Number 199684-61-2
Cyclodextrin Type Cyclodextrin Derivatives
Packaging 1 g, 3 g
Quality Fine chemical grade
Storage Condition Store in an airtight container at room temperature.
Availability In stock
*On-demand pack size is available, please contact us for multi-kilograms pack sizes.
Product Description
Beta-Cyclodextrin Phosphate Sodium Salt is derived from beta-cyclodextrin, a cyclic oligosaccharide consisting of seven glucose units linked by α-1,4-glycosidic bonds. The modification involves the phosphorylation of hydroxyl groups on the cyclodextrin ring, introducing phosphate groups that are neutralized by sodium ions. This phosphorylation alters the surface properties of beta-cyclodextrin, improving its water solubility, thermal stability, and chemical reactivity.
Basic Information
| Molecular Formula | C42H70-nO35·(NaHPO3)n |
| Formula Weight | 1135.0+n·(102.0) |
| Possible Impurities | Beta-cyclodextrin, sodium phosphate, sodium pyrophosphate |
| Solubility (in 100 cm3 solvent, at 25 °C) | Water: >50 g, Methanol:<1 g, Chloroform: <1 g |
Detailed Information
Physical & Chemical Properties
| Appearance | white to slight yellow powder |
| Average degree of substitution (n) | 2.0-6.0 |
| Purity | >92% |
| Loss on drying | <20% |
Impurities
| Residual sodium phosphate (expressed as trisodium phosphate) | <3% |
| Residual sodium pyrophosphate (expressed as tetrasodium pyrophosphate) | <3% |
| Residual Beta-Cyclodextrin | <2% |
Key Chemical Properties
- Solubility: Highly soluble in water due to the presence of phosphate groups, which enhance hydrophilicity.
- Thermal Stability: Improved stability compared to native beta-cyclodextrin, making it suitable for applications requiring heat resistance.
- Complexation Ability: Retains the encapsulation capability of beta-cyclodextrin, allowing for the formation of host-guest complexes with a wide range of molecules, including hydrophobic drugs, flavors, and fragrances.
- Biodegradability: Environmentally friendly, with excellent biodegradability, making it a sustainable choice for industrial applications.
Phosphorylation Process
The synthesis of Beta-Cyclodextrin Phosphate Sodium Salt typically involves the phosphorylation of beta-cyclodextrin using phosphoric acid derivatives, such as sodium trimetaphosphate or phosphorus oxychloride, under controlled conditions. The reaction parameters, such as pH, temperature, and reaction time, are optimized to achieve the desired degree of substitution and product purity.
A. Beta-cyclodextrin is dissolved in an aqueous solution containing a phosphorylating agent.
B. The reaction is initiated by adjusting the pH and temperature, facilitating the attachment of phosphate groups to the hydroxyl sites of the cyclodextrin ring.
C. Post-reaction, the mixture is neutralized with sodium hydroxide, resulting in the formation of the sodium salt. The product is then purified by dialysis or precipitation methods to remove unreacted reagents and by-products.
D. The purified product is dried and characterized using techniques such as Nuclear Magnetic Resonance (NMR), Infrared Spectroscopy (IR), and High-Performance Liquid Chromatography (HPLC) to confirm the degree of substitution and product quality.
Applications
- β-CDP-Na enhances the solubility and bioavailability of poorly water-soluble drugs, making it an effective excipient in drug formulation. Its encapsulation capability aids in the controlled release of active pharmaceutical ingredients (APIs), improving therapeutic efficacy and patient compliance.
- In the food industry, β-CDP-Na is used to encapsulate flavors, enhancing their stability and prolonging shelf life. It masks undesirable tastes and odors, making it valuable in the development of functional foods and beverages.
- In cosmetics, β-CDP-Na is used to encapsulate active ingredients, such as vitamins, antioxidants, and essential oils, protecting them from degradation and enhancing their bioavailability upon application.
Related Products
Alfa Chemistry leverages over two decades of expertise in cyclodextrin chemistry to offer high-quality, customizable beta-cyclodextrin phosphate sodium salt tailored to your application needs. Our state-of-the-art production facilities and rigorous quality control ensure consistent performance and compliance with the highest industry standards. For more information or to request a quote, please contact us.
It should be noted that our our products and services are for research use only, not for clinical use.
