Azelaic Acid-Hydroxypropyl-Beta-Cyclodextrin
INQUIRY
Azelaic Acid-Hydroxypropyl-Beta-Cyclodextrin
Catalog CD-IC01
Cyclodextrin Type Cyclodextrin inclusion complex
Packaging 10 kg, 15 kg, 20 kg
Storage Condition Store in a tightly sealed container away from heat and direct light, and in a cool dry place
Uses Excipient
Availability In stock
*On-demand pack size is available, please contact us for multi-kilograms pack sizes.
Product Description
Azelaic acid-hydroxypropyl-beta-cyclodextrin, abbreviated as azelaic acid-HP-β-CD, is an inclusion complex obtained from azalaic acid and HP-β-CD.
Azelaic acid is a dicarboxylic acid molecule with anti-inflammatory and antioxidant properties, which inhibits and kills a variety of aerobic and anaerobic bacteria that cause acne. It acts as an exfoliant to promote skin cell turnover and unclogs pores. When applied topically, azelaic acid reduces free fatty acid and lipid formation on the skin, which is useful for treating skin diseases such as acne vulgaris and papulopustular rosacea. Moreover, azelaic acid inhibits tyrosine, which reduces pigmentation, so it's particularly useful for dark-skinned people who have acne spots that leave persistent brown marks or suffer from melasma.
- Reasons for developing our product
Azelaic acid is safe and suitable for most people. However, those with very sensitive skin may find it irritating to apply. In addition to causing dryness and irritation of the skin, high-concentration azelaic acid products may have an irritating effect on the eyes, mucous membranes, and upper respiratory tract. Besides, the poor water solubility of azelaic acid makes it difficult to formulate this substance for topical applications [1].
- Advantages of our product
In order to avoid the problems mentioned above, azelaic acid molecules are embedded in the cavity of HP-β-CD to form a water-soluble azelaic acid-HP-β-CD inclusion complex via molecular capsule technology. The inclusion compound has excellent oil control properties, and it not only maintains the function of azelaic acid, but also avoids certain irritating effects of free azelaic acid on the skin, eyes, mucous membranes and upper respiratory tract. It also improves the water solubility of azelaic acid. Therefore, the inclusion complex, azelaic acid-HP-β-CD, is more conducive to the use of azelaic acid in cosmetics and care products, greatly expanding the uses of azelaic acid.
Specification
| Appearance | White powder |
| Azelaic acid content | 10.0% - 15.0% |
| Solubility (in 100 cm3 solvent, at 20 °C) | Water: > 20.0 g |
| Residue on ignition | Max. 0.5% |
| Heavy metals | Max. 10 ppm |
| Loss on drying | Max. 6.0% |
| Residual chloride | Max. 1.0% |
| Total aerobic microbial count (TAMC) | Max. 1000 cfu/g |
| Total yeast and mold count (TYMC) | Max. 100 cfu/g |
| Escherichia coli | Not detectable |
Applications
Azelaic acid HP-β-CD inclusion complex overcomes the problem of poor solubility of azelaic acid, enabling the preparation of lotions and essences easily. It also greatly reduces the irritation caused by azelaic acid. This CD-based inclusion compound we prepared has broadened the application of azelaic acid, which better exerts the effects of azelaic acid as well.
- The product can be used in facial masks and lotions to control oil secretion, as azelaic acid inhibits excessive secretion of oil.
- The product can be used for anti-acne products, since azelaic acid possesses good bactericidal and anti-inflammatory effects.
- The product can be used in whitening products as a whitening formula to better exert the effect of azelaic acid on whitening and lightening spots.
Related Products
As one of the leading CD companies, Alfa Chemistry has a dedicated team which has accumulated extensive expertise in the field of CD chemistry. We offer a new water-soluble azelaic acid-HP-β-CD inclusion complex in multi-kilogram quantities tailored to the special needs of the cosmetic industry. We do our best to provide customers with first-class products and services. For more information, please feel free to contact us.
Reference
- Manosroi, J.; et al. Enhancement of the release of azelaic acid through the synthetic membranes by inclusion complex formation with hydroxypropyl-beta-cyclodextrin. Int J Pharm. 2005, 293(1-2): 235-40.
It should be noted that our our products and services are for research use only, not for clinical use.
