(2-Hydroxypropyl)-Gamma-Cyclodextrin

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(2-Hydroxypropyl)-Gamma-Cyclodextrin

Abbreviation HPGCD

Catalog CD128446344

CAS Number 128446-34-4

Cyclodextrin Type Substituted cyclodextrins, neutral

Packaging 10 kg

Storage Condition Store at room temperature, in tightly closed container

Availability In stock

*On-demand pack size is available, please contact us for multi-kilograms pack sizes.

Product Description

(2-Hydroxypropyl)-gamma-cyclodextrin, abbreviated as HP-γ-CD or HPGCD, is a cyclic oligosaccharide composed of glucopyranose units and is shaped like a hollow truncated cone. It is a hydroxyalkyl derivative of native γ-CD (8-glucose units). HPGCD is no longer a single pure product, but a mixture of multiple substitutions. As with other CDs, HPGCD has inclusion properties but it has strong anti-crystallization ability and is not easy to form inclusion complex crystals when clathrated with guest molecules. It can encapsulate larger molecules, such as cholesterol. Besides, HPGCD can also cross-link to form long chain polymers and is considered a very useful chemical in supramolecular chemistry. Custom bulk orders of this product are available upon request.

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Detailed Information

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Applications

One of the most soluble CD derivatives is hydroxypropyl-CDs, which are non-toxic and completely soluble in water. As a type of hydroxypropyl-CD, HPGCD can effectively encapsulate many bulky molecules due to its large cavity diameter and is widely used in the pharmaceutical industry as a pharmaceutical excipient ^[1]. It can not only include drugs with specific functions to improve the bioavailability of drugs, but also alleviate cholesterol accumulation to provide new treatments for certain diseases. The following are two specific application examples of HPGCD.

• HPGCD was used to enhance the properties of curcumin by forming an inclusion complex, with curcumin being a drug that accelerates wound healing. A curcumin-HPGCD complex was prepared in sacran (a novel megamolecular polysaccharide)-based hydrogel film (HGF), which not only enhances the antioxidant activity of curcumin, but also helps curcumin delivery. The complex has potential for use as a new transdermal therapeutic system to enhance curcumin's wound healing activity ^[2].
• HPGCD was used to alleviate cholesterol accumulation in NPC1-deficient cells. Mutations in the NPC1 gene cause Niemann-Pick type C disease (NPC), a fatal neurological disorder characterized by the accumulation of cholesterol in the lysosomes. It was proven that HPGCD improves cholesterol levels and cellular homeostasis in conditions of NPC1 deficiency by increasing lysosomal function and dynamics, which may contribute to effective NPC and related lysosomal storage disorder therapies ^[3].

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As one of the leading CD companies, Alfa Chemistry has a dedicated team which has accumulated extensive expertise in the field of CD chemistry. We offer high quality HPGCD in multi-kilogram quantities tailored to the special needs of the pharmaceutical and other industries. We do our best to provide customers with first-class products and services. For more information, please feel free to contact us.

It should be noted that our our products and services are for research use only, not for clinical use.