(2-Hydroxypropyl)-Gamma-Cyclodextrin

Feng W, et al. International Journal of Biological Macromolecules, 2024, 270, 132344.

(2-Hydroxypropyl)-Gamma-Cyclodextrin (HPγCD) was utilized to enhance the electrospinning process for fabricating luteolin-loaded nanofibers, demonstrating its role in drug solubilization and controlled release. A physical mixture of luteolin (Lut) and HPγCD was initially prepared in an equimolar ratio, followed by grinding and vacuum drying. To improve the solubility and dispersion of Lut, an inclusion complex (Lut/HPγCD-IC) was formed by dissolving HPγCD in water and mixing it with Lut at a 1:4 molar ratio. The resulting complex was stirred at 25°C for 12 hours, yielding an electrospinning solution.

Electrospinning was performed with a metal needle injector at a controlled flow rate of 8 μL/s, a voltage of 15-20 kV, and a collection distance of 15-17 cm. The process successfully generated HPγCD nanofibers (HPγCD-NF) and Lut/HPγCD-IC nanofibers (Lut/HPγCD-IC-NF), which were stored at 3°C before further characterization. The study highlights HPγCD's efficacy in forming stable inclusion complexes and facilitating electrospinning for advanced pharmaceutical applications.

Yamada Y, et al. Life Sciences, 2024, 350, 122776.

2-Hydroxypropyl-γ-cyclodextrin (HP-γ-CD), a cyclic octasaccharide, has demonstrated therapeutic potential in treating Niemann-Pick disease type C (NPC). In a murine model, HP-γ-CD exhibited superior biocompatibility compared to 2-hydroxypropyl-β-cyclodextrin (HP-β-CD), a related cyclic heptasaccharide under clinical investigation. Experimental results revealed that HP-γ-CD effectively modulated cholesterol homeostasis within hours post-exposure, with sustained effects lasting several days. Biodistribution studies indicated that systemically administered HP-γ-CD exhibited limited penetration into peripheral organs, including the brain and liver. Notably, while subcutaneous administration failed to alleviate neurological symptoms due to its poor blood-brain barrier permeability, intracerebroventricular administration significantly mitigated hepatic dysfunction despite the absence of detectable HP-γ-CD in the liver. These findings suggest that central administration of HP-γ-CD may exert indirect systemic benefits, potentially mediated through neurological pathways.

Liu B, et al. Journal of Molecular Structure, 2024, 1299, 137195.

(2-Hydroxypropyl)-Gamma-Cyclodextrin (HPγCD) was utilized to improve the solubility and antifungal efficacy of hexaconazole (HEZ) through the fabrication of HEZ/HPγCD inclusion complex nanofibers (HEZ/HPγCD-IC-NF). The preparation involved first dissolving HPγCD in distilled water (180%, w/v) and subsequently mixing it with HEZ powder at a 1:1 stoichiometric ratio. The solution was stirred at 25 °C for 12 h to form the HEZ/HPγCD-IC solution. Electrospinning was then performed using a sterile syringe loaded with the solution, maintaining a flow rate of 0.5 mL h⁻¹, a needle-to-collector distance of 18 cm, and an applied voltage of 15 kV at 25 °C and 30% humidity. The resulting nanofibers demonstrated complete encapsulation of HEZ, leading to enhanced thermal stability, water solubility, and a 1.92-fold increase in antifungal activity against Botrytis cinerea compared to free HEZ. This study highlights HPγCD's role in electrospinning-mediated drug delivery, offering a promising approach for improving the bioavailability and efficacy of hydrophobic agrochemicals.

Yang G, et al. Industrial Crops and Products, 2024, 211, 118282.

(2-Hydroxypropyl)-γ-cyclodextrin (HPγCD) plays a crucial role in the electrospinning synthesis of antifungal nanofibers incorporating prochloraz. In this study, HPγCD was employed to enhance the solubility and stability of prochloraz by forming an inclusion complex, enabling its efficient incorporation into nanofibers via electrospinning. The preparation involved dissolving 1.6 g of HPγCD in 1 mL of distilled water, followed by the addition of 0.381 g of prochloraz (molar ratio 1:1). The resulting solution underwent 12 hours of stirring at 600 rpm before being electrospun at 15-20 kV under controlled conditions (25°C, 20% RH). The electrospun nanofibers, deposited on an aluminum foil receiving plate, demonstrated potential as an effective antifungal delivery system.

Gao S, et al. Industrial Crops and Products, 2022, 176, 114300.

This study investigates the use of (2-Hydroxypropyl)-Gamma-Cyclodextrin (HPγCD) in the preparation of an inclusion complex with perillaldehyde (PA), synthesized into nanofibers through electrospinning. The preparation of the PA/HPγCD inclusion complex (PA/HPCD-IC) involved dissolving 2 g of HPγCD in 1 mL of distilled water, followed by mixing with an equimolar amount of PA and stirring for 24 hours at room temperature to form the PA/HPγCD-IC solution. This solution was then subjected to electrospinning, where the inclusion complex nanofibers were produced without blending the HPγCD with a polymer matrix. The electrospinning process was performed using a syringe pump at a voltage of 15-17 kV and a spray rate of 0.5 mL/h, with a collector distance of 15-17 cm. The resulting nanofibers were stored at 4°C for further analysis.

The experiment highlights the effective role of HPγCD in enhancing the solubility and stability of PA through the formation of inclusion complexes, which are then successfully fabricated into nanofiber membranes.