(2-Hydroxypropyl)-Beta-Cyclodextrin

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(2-Hydroxypropyl)-Beta-Cyclodextrin

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(2-Hydroxypropyl)-Beta-Cyclodextrin

Abbreviation HPBCD

Catalog CD128446355

CAS Number 128446-35-5

Cyclodextrin Type Substituted cyclodextrins, neutral

Packaging 20 kg

Storage Condition Store at room temperature, in tightly closed container

Availability In stock

*On-demand pack size is available, please contact us for multi-kilograms pack sizes.

Product Description

2-Hydroxypropyl-beta-cyclodextrin, abbreviated as HP-β-CD or HPBCD, is a cyclic oligosaccharide composed of glucopyranose units, with the molecule structure shaped like a hollow truncated cone. HPBCD is obtained by replacing the hydrogen atoms of the hydroxyl groups at positions 2, 3, and 6 of the glucose residue in β-CD with hydroxypropyl groups. It is the most widely used modified CD. Not only does HPBCD have an inclusion effect, but it can also help poorly soluble drugs become more soluble and bioavailable. Due to its various advantages, it is an Food and Drug Administration (FDA)-approved drug delivery vehicle and an effective cholesterol-lowering agent ^[1].

Basic Information

Average Molecular Formula	C₄₂H_70-nO₃₅·(C₃H₇O)_n
Average Molecular Weight	1135.0 + n·(58.1)
Average degree of subtitution [DS]	0.4-1.5 (Molar substitution)
Possible Impurities	Propylene glycol, beta-CD, hydroxypropylated linear dextrins
Solubility (in 100 cm³ solvent, at 25 °C)	Water: > 33 g Methanol: > 33 g DMF: > 33 g

Detailed Information

Physical & Chemical Properties

Appearance	White or almost white, amorphous or crystalline powder
Appearance of aqueous solution (1.0 g/2 ml)	The solution is clear and colorless
Conductivity (25 °C, 1% solution in water)	Max. 200 µS/cm
Loss on drying	Max. 10.0%

Identification

Identification: IR	Conplies with reference standard
Identification: Clarity of solution	1 g dissolved in 2 mL of water with heating is clear and colorless and remains so after cooling
Identification: Average degree of substitution	Meets requirements

Impurities

Residual beta-cyclodextrin (β-CD)	Max. 1.5%
Residual propylene glycol	Max. 2.5%
Residual propylene oxide	Max. 1 ppm
Any other single impurity	Max. 0.25%
Total other impurities	Max. 1.0%
Heavy metals	Max. 5 ppm

Microorganism

Total aerobic microbial count (TAMC)	Max. 1000 cfu/g
Total yeast and mold count (TYMC)	Max. 100 cfu/g
Baterial endotoxins	Max. 10 EU/g

Applications

(2-Hydroxypropyl)-Beta-Cyclodextrin

HPBCD is a substitute for β-CD, which not only has the inclusion properties of β-CD, but also has better water solubility and safe cytotoxicity ^[2]. Therefore, in the pharmaceutical field, HPBCD could serve as a stabilizer and penetration enhancer for drugs, which is of great significance for drug delivery and improving the bioavailability of drugs ^[3]. In the food field, HPBCD can specifically interact with food-derived compounds by forming non-covalent bonded units, so it can stabilize unstable compounds such as pigments, supplying new thought for extending the shelf life of food ^[4]. The following are two specific application examples of HPBCD in the pharmaceutical and food fields.

HPBCD was used to graft with polyethylenimines (PEI) of different molecular weights to prepare cationic polymers HPBCD-PEI. These polymers based on HPBCD have biodegradability and great biocompatibility that could act as penetration enhancers to enhance the penetration of hydrophilic drugs, making them valuable for topical drug delivery ^[3].
HPBCD was used to encapsulate phycocyanin (PC) to form an inclusion complex, which significantly improved the pH, heat and light tolerance and antioxidant activity of PC. In a blue beer developed using HPBCD-PC inclusion complex as a colorant, the encapsulation effect of HPBCD increased the temperature stability and light stability of beer, thereby extending its shelf life ^[4].

Related Products

As one of the leading CD companies, Alfa Chemistry has a dedicated team which has accumulated extensive expertise in the field of CD chemistry. We offer high quality HPBCD in multi-kilogram quantities tailored to the special needs of the pharmaceutical and other industries. We do our best to provide customers with first-class products and services. For more information, please feel free to contact us.

References

Nicole, E.-D.; et al. 2-Hydroxypropyl-β-cyclodextrin reduces retinal cholesterol in wild-type and Cyp27a1-/- Cyp46a1-/- mice with deficiency in the oxysterol production. Br J Pharmacol. 2021, 178(16): 3220-3234.
Gould, S.; Scott, R. C. 2-Hydroxypropyl-beta-cyclodextrin (HP-beta-CD): a toxicology review. Food Chem Toxicol. 2005, 43 (10): 1451-9.
Wang, K.; et al. In vitro and in vivo application of hydroxypropyl-β-cyclodextrin-grafted polyethyleneimine used as a transdermal penetration enhancer. Polym. Chem. 2014, 5: 4658-4669.
Zhang, G.; et al. Complexation of phycocyanin with hydroxypropyl-β-cyclodextrin and its application in blue beer containing quinoa saponins as foaming agents. Front. Nutr. 2023, 10: 1209193.

It should be noted that our our products and services are for research use only, not for clinical use.

Product Description

Basic Information

Detailed Information

Applications

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