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Fmoc-Protected Amino Acids
Welcome to Alfa Chemistry, your trusted global partner in high-purity amino acid derivatives. As a leading chemical supplier, we specialize in providing premium-grade Fmoc-Amino Acids tailored to meet the rigorous demands of modern peptide synthesis, drug discovery, and biochemical research.
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Overview
What Are Fmoc-Amino Acids?
Fmoc-Amino Acids (N-ɑ-(9-fluorenylmethyloxycarbonyl) amino acids) are the gold standard building blocks in solid-phase and solution-phase peptide synthesis. Because the Fmoc protecting group is stable under acidic conditions and can be efficiently cleaved under mild basic conditions (typically using piperidine), it prevents unwanted side reactions and racemization.
Functions
What Are the Functions of Fmoc-Amino Acids?
In peptide synthesis, protecting groups are essential to direct chemical reactions specifically where intended. Fmoc-Amino Acids perform crucial functions:
Alpha-Amino Protection
Temporarily shields the ɑ-amino group to prevent premature polymerization during peptide bond formation.
Base-Labile Cleavage
Allows selective removal of the protective group using mild secondary amines (e.g., 20% piperidine in DMF) without affecting side-chain protecting groups or the growing peptide-resin anchor.
Minimizing Side Reactions
Designed to suppress racemization, deletion sequences, and premature chain termination, yielding higher-purity crude peptides.
Products
What Fmoc-Amino Acids Do We Offer?
We offer an extensive catalog of Fmoc-protected amino acid derivatives categorized to suit every synthetic requirement:
Standard Proteinogenic Fmoc-Amino Acids
All 20 natural L-amino acids (e.g., Fmoc-Ala-OH, Fmoc-Gly-OH, Fmoc-Leu-OH).
D-Amino Acid Derivatives
Enantiomerically pure D-form building blocks for retro-inverso peptides and specialized drug design (e.g., Fmoc-D-Ala-OH).
Side-Chain Protected Derivatives
Amino acids equipped with orthogonal side-chain protecting groups (Trt, Boc, tBu, Pbf, etc.) for complex multifunctional peptides.
Unnatural & Modified Amino Acids
Fluorinated, methylated, N-methylated, and isotopically labeled amino acids for structural studies and metabolic stability enhancement.
Applications
What Are Fmoc-Amino Acids Used for?
Our high-purity Fmoc-Amino Acids serve diverse high-tech industries and research fields:
Therapeutic Peptide & Vaccine Development
Synthesizing therapeutic peptide candidates, GLP-1 receptor agonists, and synthetic vaccines.
Biochemical & Proteomic Research
Creating custom peptides for enzyme assays, receptor binding studies, and antibody production.
Materials Science
Building peptide-based hydrogels, biosensors, and self-assembling biomaterials.
Combinatorial Chemistry
Generating vast peptide libraries for high-throughput screening in drug discovery.
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Customer Cases
Curious About Our Success Stories?
Case 1Case 2Case 3
Case 1: Kilogram-Scale Supply of N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-β-alanine for Beta-Peptide Drug Development
Client: A clinical-stage biopharmaceutical enterprise specializing in novel beta-peptide therapeutics in Boston, USA.
Challenge: The client required a 5 kg batch of N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-beta-alanine (Fmoc-beta-Ala-OH) with a guaranteed chemical purity of ≥ 99.0% and strictly controlled residual solvents to support an upcoming Phase II clinical trial. Previous suppliers had struggled with batch-to-batch coloration issues and low coupling yields during automated SPPS elongation.
Solution: Leveraging our advanced recrystallization and chromatographic purification technologies, Alfa Chemistry delivered the 5 kg lot within 18 days. Independent HPLC analysis verified a 99.3% purity and an optical enantiomeric excess of >99.5%.
Result: The material successfully eliminated premature chain termination during solid-phase assembly, resulting in an overall crude peptide yield increase of 14% and saving the client over two weeks of optimization time.
Case 2: High-Purity 4-tert-Butyl N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartate for Complex Multi-Epitope Vaccine Synthesis
Client: A leading European vaccine research institute and biotech consortium.
Challenge: During the synthesis of a complex 45-amino-acid long polypeptide vaccine candidate, the researchers faced severe undesired side reactions, specifically base-catalyzed aspartimide formation and subsequent piperidine-induced ring-opening side products. They urgently needed a highly reliable source of 4-tert-Butyl N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartate (Fmoc-Asp(OtBu)-OH) with minimal free acid impurities (≤ 0.1%).
Solution: Alfa Chemistry provided a tailored batch of Fmoc-Asp(OtBu)-OH featuring ultra-low free acid content ($0.05\%$) and rigorous moisture control (≤ 0.15% by Karl Fischer titration).
Result: The implementation of our high-purity raw material reduced aspartimide-related impurities by 92% as quantified by analytical LC-MS, allowing the team to successfully scale up their target polypeptide synthesis to multi-gram quantities with a final isolated purity of ≥ 98.5%.
Case 3: Custom Enantiomeric Purity Assurance for Nα,Nε-Bis[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine in Branched Peptide Engineering
Client: A contract research and manufacturing organization (CMO) in Tokyo, Japan, developing branched antimicrobial dendrimers.
Challenge: The synthesis of multi-branched lysine cores required dual-protected Nα,Nε-Bis[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine (Fmoc-Lys(Fmoc)-OH) with absolute chiral integrity. Even trace levels (>0.1%) of the D-isomer could trigger devastating diastereomeric mixtures that were nearly impossible to separate via preparative HPLC.
Solution: Our technical team performed stringent chiral gas/liquid chromatography screening on our stock of Fmoc-Lys(Fmoc)-OH, verifying an enantiomeric purity (ee) of 99.8%, backed by a comprehensive 500 MHz 1H-NMR structural verification report.
Result: The client completed a 500-reaction high-throughput library screen without a single batch failure due to racemization, slashing their downstream purification overhead costs by approximately 30%.
Customization
Can You Request Custom Synthesis or Bulk Supply?
Cannot find the exact derivative you need in our standard catalog? We provide flexible custom synthesis services.
Custom Derivatization • Bulk & Commercial Scale • Specialized Packaging
Reviews
What Do Researchers Say About Our Products?
Average Rating
4.9
Customers reviews
Common questions
What Our Customers Ask
Q: What is the typical shelf life of your Fmoc-Amino Acids?
A: When stored properly in a cool, dry, and dark place (typically 2-8 °C or -20°C depending on the specific derivative), most Fmoc-Amino Acids remain stable for 2–3 years.
Q: Do you provide Certificates of Analysis (COA) with each batch?
A: Yes, every single shipment includes a detailed COA featuring HPLC purity, NMR data, and optical rotation values.
Q: Can you accommodate custom packaging for automated synthesizers?
A: Absolutely. We offer custom weighing and specialized vial packaging to fit automated peptide synthesizer racks.
Q: Do you offer bulk discounts or custom supply agreements for commercial peptide manufacturing?
A: Yes. We support customers ranging from academic labs to commercial-scale pharmaceutical manufacturers. We offer tiered volume pricing, customized delivery schedules, and dedicated supply agreements to ensure uninterrupted production lines. Contact our sales team to discuss your annual forecast.
Q: What are your standard lead times and shipping conditions for in-stock Fmoc-Amino Acids?
A: In-stock standard Fmoc-Amino Acids are typically dispatched within 24–48 hours. We ship worldwide using temperature-controlled or standard packaging depending on the chemical stability of the specific derivative to ensure products arrive in optimal condition. Expedited air freight options are also available upon request.
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Stay informed with the latest updates from our company, where we continually innovate and enhance our services to meet your needs.
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