CAS 1246833-58-8 Zuclopenthixol Succinate Salt

Synonyms

4-[(3Z)-3-(2-Chloro-9H-thioxanthen-9-ylidene)propyl]-1-piperazineethanol Succinate; (Z)-Clopenthixol-Succinate; Cisordinol Succinate; Clopixol Succinate; cis-(Z)-Clopenthixol Succinate; cis-Clopenthixol Succinate; α-Clopenthixol Succinate

Molecular Weight

519.05

Molecular Formula

C₂₆H₃₁ClN₂O₅S

Melting Point

56-60° C

Purity

98%

Storage

-20°C storage

Application

Zuclopenthixol Succinate Salt is intended for use as an antipsychotic medication aimed at treating conditions such as schizophrenia and bipolar mania. Acting as a thioxanthene-based neuroleptic, it primarily functions by antagonizing dopamine D1 and D2 receptors, effectively reducing symptoms linked to excessive dopamine activity in the brain. In addition to its main dopamine receptor activity, Zuclopenthixol also interacts with serotonin 5-HT2 and 5-HT6 receptors, α1-adrenergic receptors, and histamine receptors, although it shows no significant binding to α2-adrenergic receptors. Interestingly, it can also inhibit the cAMP accumulation induced by dopamine, adding another layer to its therapeutic effects. Zuclopenthixol Succinate Salt is also a critical component in the synthesis of its long-acting formulation, Zuclopenthixol Decanoate, which is used for the maintenance treatment of chronic schizophrenia. The purpose of this substance is to provide an effective and comprehensive approach to mitigating psychotic symptoms, thereby enhancing the quality of life for individuals with severe mental health disorders.

December 14, 2024

Excellent Tool for Dopamine Research

Zuclopenthixol Succinate Salt greatly enhanced our neuroscience studies by effectively inhibiting dopamine activity. Easy to integrate into assays, it offers reliable results in behavioral experiments. A must-have for research labs.