CAS 1447963-75-8 tBuXPhos Pd G3 - Catalysts / Alfa Chemistry

Application

tBuXPhos Pd G3 is a versatile third generation Buchwald precatalyst, designed to enhance synthetic reactions in both research and industrial settings. It is particularly effective in catalyzing the Buchwald-Hartwig cross-coupling reactions and demonstrates exceptional stability against air, moisture, and heat. Thanks to its high solubility in many common organic solvents, tBuXPhos Pd G3 ensures prolonged usability in solutions. This precatalyst facilitates the efficient synthesis of 4-cyano-7-azaindole from 4-chloro-7-azaindole through cyanation, and supports α-arylation reactions of acetate esters even at room temperature. One of its standout features is the ability to operate with lower catalyst loadings and reduced reaction times while providing precise control over the ligand-to-palladium ratio. Furthermore, it enables mild palladium-catalyzed cyanation of (hetero)aryl halides and triflates in aqueous environments, making it an indispensable tool for achieving efficient and controlled chemical transformations.