Application
SPhos Pd G1, Methyl t-Butyl Ether Adduct is utilized as a catalyst to facilitate and enhance chemical reactions, particularly in the synthesis of CDK 8/19 inhibitors. These inhibitors are important for the development of novel and selective compounds that can minimize CYP3A4 time-dependent inhibition. The product is central to studies investigating the impact of ligand structure on reductive elimination and is also featured in application guides for palladium-catalyzed cross-coupling reactions. Moreover, it serves as an effective catalyst in forming carbon-nitrogen (C-N) bonds, showcasing its versatility in various organic synthesis processes.