(S)-(+)-(3,5-dioxa-4-phospha-cyclohepta[2,1-a:3,4-a']dinaphthalen-4-yl)bis[(1R)-1-phenylethyl]amine, dichloromethane adduct

Application

(S)-(+)-(3,5-dioxa-4-phospha-cyclohepta[2,1-a:3,4-a']dinaphthalen-4-yl)bis[(1R)-1-phenylethyl]amine, dichloromethane adduct serves as a versatile organic catalyst with applications in chirality-driven synthesis. It plays a crucial role in the stereoselective generation of homoallylic nitriles and is essential as a ligand for the asymmetric conjugate addition of dialkyl zinc reagents to activated olefins. This catalyst is further utilized in several sophisticated transformation processes, including the iridium-catalyzed enantioselective addition of nucleophiles to achiral allylic esters, regio- and enantioselective Friedel-Crafts allylic alkylation of indoles, and asymmetric hydrogenation. Additionally, it is involved in high precision reactions such as asymmetric hydrovinylation, 1,3-dipolar cycloaddition of azomethine ylides and alkenes, Rh-catalyzed [5+2] cycloaddition of alkyne-vinyl-cyclopropanes, and palladium-catalyzed enantioselective processes including de-epimerization in asymmetric allylic alkylation and diamination of alkyl dienes.