(R)-(-)-1-[(S)-2-(Di-tert-butylphosphino)ferrocenyl]ethyldi-(4-trifluoromethylphenyl)phosphine

Application

The purpose of (R)-(-)-1-[(S)-2-(Di-tert-butylphosphino)ferrocenyl]ethyldi-(4-trifluoromethylphenyl)phosphine, an orange powder, is to serve as a versatile ligand in various catalytic reactions. Developed at Solvias in Basel, Switzerland, this asymmetric ferrocenylphosphine ligand facilitates the stereoselective synthesis of numerous commercial products. Its uniqueness lies in the fixed phosphine moiety combined with a stereogenic, functionalized side chain that can be tailored to meet specific electronic and steric requirements. This ligand finds broad applications in processes such as Pd-catalyzed C-N bond formation, enantioselective alkylative desymmetrization of meso-succinic anhydrides, asymmetric hydrogenation of ketones and phosphinylketimines, and more. It also plays a crucial role in Cu-catalyzed reductions, rhodium-catalyzed asymmetric reactions, and serves as a catalyst or ligand in several other synthetic procedures, making it an integral component in modern chemical transformations, with its commercialization supported through collaboration with Solvias AG.