CAS 364732-88-7 (R)-Phanephos - Catalysts / Alfa Chemistry

Synonyms

(R)-(-)-4,12-Bis(diphenylphosphino)-[2.2]-paracyclophane

Molecular Weight

576.65

Molecular Formula

C40H34P2

InChI

1S/C40H34P2/c1-5-13-35(14-6-1)41(36-15-7-2-8-16-36)39-29-31-21-25-33(39)27-23-32-22-26-34(28-24-31)40(30-32)42(37-17-9-3-10-18-37)38-19-11-4-12-20-38/h1-22,25-26,29-30H,23-24,27-28H2

InChI Key

GYZZZILPVUYAFJ-UHFFFAOYSA-N

Melting Point

222-226 °C

Assay

0.96

Optical Activity

[α]/D -34±4°, c = 1 in chloroform

Application

(R)-Phanephos serves as a versatile and efficient ligand utilized in various catalytic reactions to achieve enantioselectivity. Its roles include facilitating rhodium-catalyzed asymmetric hydroboration of cyclopropenes, and promoting iridium-catalyzed [2+2] cycloaddition of oxabicyclic alkenes with terminal alkynes. Additionally, it is instrumental in palladium-catalyzed enantioselective hydroxycarbonylation and alkoxycarbonylation of alkenes, as well as amide synthesis through C(sp3)-H bond functionalization and CO insertion. This ligand is also key in the iridium-catalyzed diene hydrohydroxymethylation, and effectively supports the asymmetric hydrogenation of dehydroamino acids, methyl esters, and ketones.

April 16, 2025

Exceptional Ligand for Advanced Research Applications

I've successfully used (R)-Phanephos in asymmetric hydrogenation and enantioselective cycloaddition reactions. Its performance in rhodium- and palladium-catalyzed processes is remarkable, greatly enhancing reaction efficiency and selectivity in our lab experiments.