(R)-(+)-BINAP

Application

(R)-(+)-BINAP, a chiral ligand available as a white to light yellow crystalline powder, is extensively used in metal-mediated asymmetric catalysis. This compound serves as a critical component in transition metal-catalyzed reactions, such as hydrogenation and disilylation, owing to its ability to form highly selective homogeneous catalysts when combined with rhodium and ruthenium derivatives. These catalysts demonstrate remarkable efficacy in the reduction of aryl ketones, β-keto esters, and α-amino ketones, and they excel in facilitating asymmetric hydrogenation and hydroformylation of olefins, as well as asymmetric Heck reactions and isomerizations of allyls. In addition, (R)-BINAP, in combination with Ag(I), catalyzes asymmetric aldol reactions and enantioselective hetero-Diels-Alder reactions. It is also an essential precursor in NOYORI CATALYST SYSTEMS when paired with dichloro(1,5-cyclooctadiene)ruthenium, renowned for their high catalytic activity and enantioselectivity across diverse substrates. The ligand is crucial in a wide array of processes including the asymmetric Heck process, palladium-catalyzed arylation, rhodium-mediated 1,4-additions, and many other intricate catalytic applications involving cyclopropenes, enynes, stannyl enol ethers, and alkyl alcohols.