CAS 72287-26-4 Pd (dppf) Chloride(II) - Catalysts / Alfa Chemistry

Synonyms

1,1'-Bis(Diphenylphosphino)ferrocenepalladium (II) dichloride; 1,1'-Bis(diphenylphosphino)ferrocene dichloropalladium (ii); 1,1-Bis(diphenylphosphino)ferrocenedichloropalladium(ii)

Molecular Weight

731.7

Molecular Formula

C34H28Cl2FeP2Pd

InChI

1/2C17H15P.2ClH.Fe.Pd/c2*1-3-9-15(10-4-1)18(17-13-7-8-14-17)16-11-5-2-6-12-16;;;;/h2*1-13H,14H2;2*1H;;/q;;;;;+2/p-2

Metal Content

0.145

Physical State

Solid

Application

Pd (dppf) Chloride(II) serves as a versatile palladium catalyst, facilitating the chemical synthesis of a variety of compounds. Its prominent applications include acting as a catalyst in Suzuki and Stille couplings, as well as in C-C and C-N coupling reactions. It plays a crucial role in the preparation of nucleosides serving as ectonucleotidase inhibitors. The catalyst proves highly effective in the cross-coupling of secondary and normal alkyl Grignard reagents, ensuring high yield and selectivity. Additionally, it is instrumental in the Suzuki coupling of aryl boronic esters with [11C]methyl iodide, yielding functionalized [11C]toluene derivatives. The compound is also employed in Kumada cross-coupling, particularly with 1,3,5-tribromobenzene and Grignard reagents, to produce star-shaped oligothiophenes.

February 3, 2025

Highly Effective Catalyst for Cross-Coupling Reactions

I've been using Alfa Chemistry's Pd (dppf) Chloride(II) in our lab for cross-coupling reactions. It delivers excellent yields, particularly in Suzuki and Stille couplings, and it's indispensable for synthesizing functionalized nucleosides. Highly recommended for researchers!