Application
The Palladium(II) acetate/2-dicyclohexylphosphino-2,6-dimethoxy-1,1'-biphenyl (SPhos)/potassium phosphate admixture in CatKit single-use vials, containing 1.96 wt% Pd(OAc)2, serves as a highly effective catalyst for facilitating a range of palladium-catalyzed cross-coupling reactions. This product is particularly valuable in applications involving the formation of carbon-nitrogen (C-N) bonds and has been instrumental in the synthesis of novel and selective CDK8/19 dual inhibitors, eliminating their CYP3A4 time-dependent inhibition potential. By leveraging the unique biaryl phosphine based Pd(II) complexes, this admixture optimizes the reductive elimination process, ensuring efficient and reliable catalytic performance in various organic synthesis applications.
