CAS 1599466-83-7 Methanesulfonato(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II), min. 98% [BrettPhos Palladacycle Gen. 4]

Synonyms

Palladium, [dicyclohexyl[3, 6- dimethoxy- 2', 4', 6'- tris(1- methylethyl) [1, 1'- biphenyl] - 2- yl] phosphine- κP] (methanesulfonato- κO) [2'- (methylamino- κN) [1, 1'- biphenyl] - 2- yl- κC] - , (SP- 4- 3) -

Molecular Weight

920.53

Molecular Formula

C49H68NO5PPdS

Boiling Point

0 °C (32 °F)

Flash Point

0 °C (32 °F)

Appearance

off-white to beige powder

MDL Number

MFCD28411654

Symbol

GHS07

Application

Methanesulfonato(2-dicyclohexylphosphino-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl)(2'-methylamino-1,1'-biphenyl-2-yl)palladium(II), min. 98% [BrettPhos Palladacycle Gen. 4] is a robust fourth-generation Buchwald precatalyst, specifically designed to enhance the efficiency of cross-coupling reactions, including the N-arylation of amines. By incorporating a methylated amino group on its biphenyl backbone, this precatalyst overcomes the limitations of its third-generation counterparts. Its stability against air, moisture, and heat, coupled with excellent solubility in common organic solvents, makes it an ideal choice for demanding chemical processes. Its formulation allows for lower catalyst loadings and shorter reaction times, facilitating efficient formation of the active catalytic species and precise control over the ligand-to-palladium ratio, ultimately optimizing catalytic performance.

March 14, 2025

Outstanding Catalyst for Cross-Coupling Reactions

BrettPhos Pd G4 performs remarkably in N-arylation processes. Its thermal stability and efficiency in forming active species are invaluable in our research, allowing lower catalyst loadings and faster reaction times. Highly recommend for precise and effective results.