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Methanesulfonato(2-dicyclohexylphosphino-2',6'-bis(dimethylamino)-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II), 98% [CPhos Palladacycle Gen. 3]

Catalog Number
ACM1447963736
Product Name
Methanesulfonato(2-dicyclohexylphosphino-2',6'-bis(dimethylamino)-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II), 98% [CPhos Palladacycle Gen. 3]
CAS
1447963-73-6
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Molecular Weight
806.35
Molecular Formula
C41H54N3O3PPdS
Application
Methanesulfonato(2-dicyclohexylphosphino-2',6'-bis(dimethylamino)-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II), 98% [CPhos Palladacycle Gen. 3] is designed to serve as a highly effective catalyst for diverse cross-coupling reactions. Synthesized as a modification of a previous generation precatalyst through methylation of the amino group on its biphenyl backbone, this catalyst, developed by Buchwald and colleagues, exhibits excellent solubility in various organic solvents and remarkable stability. Its versatility extends to facilitating C-N bond formation and achieving high selectivity in the cross-coupling of secondary alkylzinc reagents with heteroaryl halides. Additionally, it provides completely linear-selective Negishi cross-coupling of allylzinc halides with aryl and vinyl electrophiles, highlighting its broad applicability and efficiency in complex chemical transformations.
March 12, 2025

Outstanding Catalyst for Cross-Coupling Reactions

I used CPhos Palladacycle Gen. 3 from Alfa Chemistry in cross-coupling research. Its solubility and long life were impressive, facilitating efficient C-N and linear-selective Negishi reactions. I'm extremely satisfied with its performance.

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