Methanesulfonato(2-Dicyclohexylphosphino-2',6'-diisopropoxy-1,1'-biphenyl)[2-(2'-amino-1,1'-biphenyl)]palladium(II)

Application

Methanesulfonato(2-Dicyclohexylphosphino-2',6'-diisopropoxy-1,1'-biphenyl)[2-(2'-amino-1,1'-biphenyl)]palladium(II) serves as an advanced precatalyst designed for a variety of palladium-catalyzed cross-coupling reactions. Its primary purpose is to facilitate efficient syntheses, including the Suzuki coupling of 5-p-toluenesulfonyltetrazoles with arylboronic acids to yield 1,5-disubstituted tetrazoles, as well as the Suzuki-Miyaura catalyst-transfer polycondensation (SCTP) of 3-alkylthiophenes using N-methylimidodiacetic (MIDA)-boronate monomers. Moreover, it plays a critical role in the Suzuki-Miyaura cross-coupling of aminothiophenes and simplifies C-N cross-coupling processes, including practical indole synthesis via Pd-catalyzed C-N ring formation. Characterized by its ability to form C-C, C-N, C-O, C-F, C-CF3, and C-S bonds, the compound exhibits stability in air, moisture, and heat, while maintaining high solubility in numerous organic solvents. Its design ensures lower catalyst loadings, reduced reaction times, efficient formation of the active catalytic species, and precise control over the ligand-to-palladium ratio, making it a versatile and efficient tool for synthetic applications.