CAS 1447963-75-8 Methanesulfonato[(2-Di-tert-butylphosphino-2',4',6'-triisopropyl-1,1'-biphenyl)-2-(2'-amino-1,1'-biphenyl)]palladium(II)

Molecular Weight

794.39

Molecular Formula

C42H58NO3PPdS

Purity

Metal purity 99.95

Appearance

light yellow

Color Form

powder

Empirical Formula

Pd(tBuXPhos)[2-(2'-amino-1,1'-biphenyl)](Ms)

Metal Content

13.4

Application

Methanesulfonato[(2-Di-tert-butylphosphino-2',4',6'-triisopropyl-1,1'-biphenyl)-2-(2'-amino-1,1'-biphenyl)]palladium(II) serves as an advanced reagent in various catalytic processes, including the synthesis of 4-cyano-7-azaindole from 4-chloro-7-azaindole through cyanation, and the α-arylation of acetate esters at ambient conditions. This third-generation Buchwald precatalyst is recognized for its stability against air, moisture, and heat, alongside its excellent solubility in numerous common organic solvents, providing an extended solution lifespan. It is particularly effective in Buchwald-Hartwig cross-coupling reactions, given its ability to reduce catalyst loading, shorten reaction times, form active catalytic species efficiently, and maintain precise control of the ligand to palladium ratio. Furthermore, its capability to mediate mild palladium-catalyzed cyanation of (hetero)aryl halides and triflates in aqueous media defines its versatility and efficiency in the field of synthetic chemistry.

March 16, 2025

Fantastic Catalyst for Efficient Reactions

Using tBuXPhos Pd G3 significantly improved our synthesis of 4-cyano-7-azaindole. Its stability and efficiency in Buchwald-Hartwig reactions were impressive, facilitating quick and reliable results in our research. Highly recommend for industry use.