Application
The purpose of Methanesulfonato[2-(di-1-adamantylphosphino)-3,6-dimethoxy-2',4',6'-tri-i-propyl-1,1'-biphenyl](2'-amino-1,1'-biphenyl-2-yl)palladium(II), also known as AdBrettPhos Palladacycle Gen. 3, is to facilitate the highly selective monoarylation of ammonia. This palladium catalyst, equipped with a bulky di-adamantyl BrettPhos ligand, excels in reactions that involve challenging 5-member heterocyclic substrates. Its design allows for mild reaction conditions while maintaining high selectivity, making it a powerful tool in synthetic chemistry applications involving ammonia arylation.