Application
Manganese(II) chloride hydrate serves as a versatile starting material for a variety of chemical processes, particularly in the preparation of organomanganese chloride reagents. It plays a critical role when combined with organolithium (RLi) or organomagnesium (RMgX) compounds, efficiently catalyzing the reduction of vinyl and aryl halides, facilitating the stereoselective coupling of vinyl iodides, and promoting the alkylation of enol triflates. Additionally, it is employed in Mn-Cu-catalyzed conjugate additions of RMgX to enones and Mn-catalyzed acylation of RMgX by acyl chlorides. When used with sodium borohydride (NaBH4), it acts as a diastereoselective reducing agent. Furthermore, manganese(II) chloride hydrate is instrumental in the regio- and stereoselective preparation of manganese enolates, making it a crucial component in advanced organic synthesis.