Dichlorobis(triphenylphosphine)palladium(II)

Application

Dichlorobis(triphenylphosphine)palladium(II) serves as a versatile organometallic complex known for its pivotal role in palladium-catalyzed coupling reactions, including various cross-coupling reactions such as Negishi, Suzuki, Sonogashira, and Heck reactions. As a yellow solid, it exhibits poor water solubility but can dissolve in organic solvents like toluene and benzene, with slight solubility in acetone and chloroform. This compound, adopting a square planar geometry, acts as a valuable catalyst and precatalyst across multiple reactions: it facilitates carbonylative cyclization of malonate derivatives, double allylation of activated olefins, preparation of 3-arylidene- or 3-alkenylidene tetrahydrofurans, and homocoupling of terminal alkynes. Additionally, it contributes to the cross-coupling of alkynylsilanols with aryl halides, supports direct Pd-catalyzed alkynylation of N-fused heterocycles, and assists in tandem Heck reaction/C-H functionalization as well as in the direct arylation of tautomerizable heterocycles.