Application
Dichloro(1,10-phenanthroline)palladium(ii) serves as a versatile catalyst employed in a variety of chemical transformations. It facilitates carbonylation of alkyl nitrites and is pivotal in arylation reactions. Under the Sonogashira reaction protocol, it enables multiple acetylene insertions. This compound is also crucial in cross-coupling reactions of pyridine carboxylic acid chlorides with alkylzinc reagents and plays a role in the hydrophosphinylation of alkenes and alkynes. Furthermore, it is effective in the Heck reaction as well as in regioselective and stereoselective aminohalogenation reactions. It aids in the reaction of chloroenynes and chlorodienes with Grignard reagents, leading to the synthesis of stereodefined enynes and dienes. Additionally, it influences the aggregation of the human prion protein PrP106-126, showcasing its unique utility in biochemical applications.