Di- µ -bromobis(tri- tert -butylphosphine)dipalladium(I)

Application

Di-μ-bromobis(tri-tert-butylphosphine)dipalladium(I) serves as an advanced catalyst, facilitating a variety of coupling reactions such as Suzuki, Negishi, and Buchwald-Hartwig amination. Its robust catalytic activity makes it particularly effective for C-C, C-N, and C-S bond formations, often encountered in complex organic synthesis. This catalyst is especially notable for activating aryl chlorides and handling sterically hindered or electron-rich aryl/vinyl bromides and iodides, often challenging in standard reactions. It plays a crucial role in the gamma-arylation of alpha, beta-unsaturated esters, diastereoselective arylation of 4-substituted cyclohexyl esters, and aromatic halide substitution. Its efficacy extends to facilitating rapid room-temperature alkylation of hindered aryl bromides with arylboronic acids, intermolecular α-arylation of zinc amide enolates, α-vinylation of carbonyl compounds, and thiol coupling of heteroaromatic aryl bromides, making it an indispensable tool in modern chemical synthesis.