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D,L-Stepholidine

Catalog Number
ACM16562144
Product Name
D,L-Stepholidine
Structure
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CAS
16562-14-4
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Synonyms
5,8,13,13a-Tetrahydro-3,9-dimethoxy-
IUPAC Name
3,9-dimethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline-2,10-diol
Molecular Weight
327.37
Molecular Formula
C₁₉H₂₁NO₄
Canonical SMILES
COC1=C(C=C2C3CC4=C(CN3CCC2=C1)C(=C(C=C4)O)OC)O
InChI Key
JKPISQIIWUONPB-UHFFFAOYSA-N
Melting Point
120-1220°C (lit.)
Purity
96%
Solubility
Soluble in Chloroform, Dimethyl Sulfoxide and Methanol
Appearance
Pink Solid
Storage
-20°C storage
Exact Mass
327.14700
H-Bond Acceptor
5
H-Bond Donor
2
Application
D,L-Stepholidine is a tetrahydroprotoberberine compound that acts as an agonist at dopamine D1 receptors and an antagonist at D2 receptors, designed for the prevention and treatment of neurological disorders. It is particularly effective for managing conditions such as parkinsonism, schizophrenia, and dyskinesia, including those forms induced by L-DOPA or medications used to treat schizophrenia.
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