Application
Copper(II) trifluoromethanesulfonate serves as a versatile mild Lewis acid, primarily functioning as a catalyst in various organic transformations. It efficiently facilitates the dehydration of alcohols and diols to alkenes at ambient temperatures. The compound is instrumental in generating carbenoid species from α-diazocarbonyl compounds via in situ reduction, enabling the formation of aziridines from diazo esters and imines. Its catalytic prowess extends to syn-selective aldol condensations, Friedel-Crafts alkylation and acylation reactions of aromatics, and the addition of trimethylsilyl cyanide to carbonyl compounds. Moreover, it plays a crucial role in the ring-opening of epoxides and aziridines. The product finds applications in asymmetric conjugate additions, aziridination, cycloadditions, and Kharasch oxidations, demonstrating its capability in enantioselective transformations like intramolecular aminooxygenations and the addition of organozinc reagents. It also facilitates Pd-catalyzed C-H functionalizations, diacetoxylation of olefins, and the direct arylation of α-aryl carbonyl compounds. Additionally, Copper(II) trifluoromethanesulfonate is employed in Nazarov cyclizations and the three-component coupling of amines, aldehydes, and alkynes, underscoring its broad applicability in synthetic chemistry.
