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cis-Diamineplatinum(II) dichloride

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Catalog Number
ACM15663271-4
Product Name
cis-Diamineplatinum(II) dichloride
CAS
15663-27-1
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Synonyms
cis-Dichlorodiammine platinum(II)
Molecular Weight
300.05
Molecular Formula
Pt(NH₃)2Cl2
Melting Point
270 °C(lit.)
Purity
Pt ≥65.0%
Appearance
yellow crystals
Storage
Store at RT
MDL Number
MFCD00011623
Symbol
GHS05, GHS06, GHS08
UN Number
UN 3288 6.1 / PGII
Application
Cis-Diamineplatinum(II) dichloride is a non-organic platinum-containing compound primarily used as a chemotherapeutic agent due to its alkylating properties. Its main mechanism of action involves causing cross-linking of DNA and RNA chains, targeting the N7 position of two adjacent deoxyguanylates in DNA, thereby inhibiting DNA replication. This property makes it effective against a variety of cancers, including those of the ovary, testis, lung, head, neck, bladder, neuroblastoma, nephroblastoma, and lymphomas, including Hodgkin's and non-Hodgkin's diseases. Administered intravenously, cis-Diamineplatinum(II) dichloride is known for being highly reactive with carcinomas, with its efficacy seen in treating cancers of the testicles, ovaries, head, neck, spleen, and lungs. The compound is characterized by its dual appearance as a white powder or a yellow crystalline solid, with a decomposition melting point between 268-272°C. While it is slightly soluble in water, it dissolves readily in dimethylformamide and can gradually transform into alternative forms in aqueous solutions. Users should be aware of its incompatibility with oxidizing agents, aluminum, and certain antioxidants like sodium bisulfite, which can lead to unwanted reactions.
January 2, 2025

An Essential for Cancer Research

Cis-Diamineplatinum(II) dichloride from Alfa Chemistry proved indispensable in my cancer research. It facilitated effective DNA cross-linking studies due to its reliable binding properties, enhancing our understanding of tumor growth inhibition.

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